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Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding.
J Biol Chem. 2019 Feb 8;294(6):1831-1845. doi: 10.1074/jbc.RA118.006297. Epub 2018 Dec 13.
J Biol Chem. 2019.
PMID: 30545939
Free PMC article.
Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
Bitra A, Doukov T, Croft M, Zajonc DM.
Bitra A, et al.
J Biol Chem. 2018 Jun 29;293(26):9958-9969. doi: 10.1074/jbc.RA118.003176. Epub 2018 May 2.
J Biol Chem. 2018.
PMID: 29720398
Free PMC article.
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