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Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.
J Biol Chem. 2018 Dec 14;293(50):19344-19353. doi: 10.1074/jbc.RA118.005850. Epub 2018 Oct 16.
J Biol Chem. 2018.
PMID: 30327430
Free PMC article.
A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis.
Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI.
Hargrove TY, et al.
J Biol Chem. 2020 Jul 17;295(29):9998-10007. doi: 10.1074/jbc.RA120.014064. Epub 2020 Jun 3.
J Biol Chem. 2020.
PMID: 32493730
Free PMC article.
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