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Comment
. 2012 Jun 26;109(26):10130-1.
doi: 10.1073/pnas.1207174109. Epub 2012 Jun 7.

Molecular basis of severe malaria

Kirk W Deitsch  1 , Chetan E Chitnis
Affiliations
Comment

Molecular basis of severe malaria

Kirk W Deitsch et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
P. falciparum-infected erythrocytes adhere within the microcapillary beds of various tissues and organs, causing a range of symptoms and disease severity. Parasites can express different types of PfEMP1, which bind to alternative host endothelial receptors, thereby determining where in the body the infected erythrocytes sequester and the severity of disease.
See this image and copyright information in PMC

Comment on

References

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    1. Claessens A, et al. A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. Proc Natl Acad Sci USA. 2012;109:E1772–E1781. - PMC - PubMed
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