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Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S; PGC-MDD Working Group; China Kadoorie Biobank Collaborative Group; 23andMe Research Team; Genes and Health Research Team; BioBank Japan Project; Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Meng X, et al. Nat Genet. 2024 Feb;56(2):222-233. doi: 10.1038/s41588-023-01596-4. Epub 2024 Jan 4. Nat Genet. 2024. PMID: 38177345 Free PMC article.
Genome-wide association study of adolescent-onset depression.
Grimes PZ, Mitchell BL, Thompson KN, Deng Q, Shen X, Wolfe JC, Thomas JT, Wootton RE, Adkins DE, Arirangan S, Assary E, Chatzinakos C, Dennison CA, Gangaraju SH, Jangmo A, Jeong Y, Kurvits S, Li QS, Motazedi E, Naamanka J, Nguyen TD, Nolte IM, Ota VK, Pasman JA, Shahisavandi M, Shakeshaft A, Shorter JR, Slaney C, Tesli M, Wang CA, Zubizarreta-Arruti U; PGC MDD Working Group; GLAD+; NIHR BioResource; Alemany S, Andreassen OA, Ask H, Belangero SI, Bosch R, Breen G, Bressan RA, Buil A, Byrne EM, Casas M, Copeland WE, Eley TC, Hannigan LJ, Hartman CA, Havdahl A, Hickie IB, Khandaker GM, Lehto K, Maes H, Martin NG, Neumann A, Oldehinkel AJ, Pan PM, Pan H, Pennell CE, Peterson RE, Rodriguez A, Salum GA, Vrijkotte TG, Wedow R, Whitehouse AJ, Thapar A, Larsson H, Middeldorp CM, McIntosh A, Adams MJ, Lu Y, Whalley HC, Kwong AS. Grimes PZ, et al. medRxiv [Preprint]. 2025 Sep 26:2025.09.26.25335972. doi: 10.1101/2025.09.26.25335972. medRxiv. 2025. PMID: 41040734 Free PMC article. Preprint.
A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.
Shen X, Barbu M, Caramaschi D, Arathimos R, Czamara D, David FS, Dearman A, Dilkes E, Herrera-Rivero M, Huider F, Kühn L, Lu KC, Palviainen T, Schowe AM, Shireby G, Weihs A, Wong CCY, Davyson E, Casey H, Adams MJ, Allgaier AK, Barber M, Burrage J, Caspi A, Costeira R, Dunn EC, Feldmann L, Frank J, Freisleder FJ, Gadd DA, Greimel E, Hannon E, Harris SE, Homuth G, Howard DM, Iurato S, Korhonen T, Lu TP, Martin NG, Martins J, McDermott E, Meinert S, Navarro P, Ollikainen M, Pehl V, Piechaczek C, Scherff AD, Stein F, Streit F, Teumer A, Völzke H, van Dongen J, Walker RM, Yusupov N, Arseneault L, Bell JT, Berger K, Binder E, Boomsma DI, Cox SR, Dannlowski U, Evans KL, Fisher HL, Forstner AJ, Grabe HJ, Kaprio J, Kircher T, Kopf-Beck J, Kumari M, Kuo PH, Li QS, Moffitt TE, Mulcahy H, Murphy TM, Schulte-Körne G, Mill J, Lewis CM; PGC MDD Working Group; Wray NR, McIntosh AM. Shen X, et al. Nat Ment Health. 2025;3(10):1152-1167. doi: 10.1038/s44220-025-00486-4. Epub 2025 Sep 16. Nat Ment Health. 2025. PMID: 41069367 Free PMC article.