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Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment.
J Clin Invest. 2024 Sep 5;134(20):e184171. doi: 10.1172/JCI184171.
J Clin Invest. 2024.
PMID: 39235967
Free PMC article.
No abstract available.
Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist.
Nichols DP, Morgan SJ, Skalland M, Vo AT, Van Dalfsen JM, Singh SB, Ni W, Hoffman LR, McGeer K, Heltshe SL, Clancy JP, Rowe SM, Jorth P, Singh PK; PROMISE-Micro Study Group.
Nichols DP, et al.
J Clin Invest. 2023 May 15;133(10):e167957. doi: 10.1172/JCI167957.
J Clin Invest. 2023.
PMID: 36976651
Free PMC article.
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