Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma.
Potts MA, Mizutani S, Deng Y, Vaidyanathan S, Ting KE, Giner G, Sridhar S, Shenoy G, Liao Y, Diepstraten ST, Kueh AJ, Pal M, Healey G, Tai L, Wang Z, König C, Kaloni D, Whelan L, Milevskiy MJG, Coughlan HD, Pomilio G, Wei AH, Visvader JE, Papenfuss AT, Wilcox S, Jeyasekharan AD, Shi W, Lelliott EJ, Kelly GL, Brown KK, Strasser A, Herold MJ.
Potts MA, et al.
Nat Commun. 2025 Aug 21;16(1):7582. doi: 10.1038/s41467-025-62615-y.
Nat Commun. 2025.
PMID: 40841511
Free PMC article.
To identify new lymphoma driving processes that cooperate with oncogenic MYC, which is abnormally highly expressed in ~70% of human cancers, we use a genome-wide CRISPR gene knockout screen in E-Myc;Cas9 transgenic hematopoietic stem and progenitor cells in vivo. We discov …
To identify new lymphoma driving processes that cooperate with oncogenic MYC, which is abnormally highly expressed in ~70% of human cancers, …