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Page 1
Showing results for prazosin p
Search for Plavosin P instead (1 results)
Clinical pharmacokinetics of prazosin.
Jaillon P. Jaillon P. Clin Pharmacokinet. 1980 Jul-Aug;5(4):365-76. doi: 10.2165/00003088-198005040-00004. Clin Pharmacokinet. 1980. PMID: 6994981 Review.
Preliminary studies in humans indicate that pathways for biotransformation of prazosin are similar to those observed in the rat and dog. Only 6% of prazosin is excreted unchanged, mainly in the urine. ...In both cases, the plasma free fraction of prazosin is …
Preliminary studies in humans indicate that pathways for biotransformation of prazosin are similar to those observed in the rat and d …
The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats.
Rasmussen DD, Alexander LL, Raskind MA, Froehlich JC. Rasmussen DD, et al. Alcohol Clin Exp Res. 2009 Feb;33(2):264-72. doi: 10.1111/j.1530-0277.2008.00829.x. Epub 2008 Nov 19. Alcohol Clin Exp Res. 2009. PMID: 19032582 Free PMC article.

RESULTS: Prazosin significantly reduced (p < 0.01) alcohol intake during the initial 2 daily administrations, and this reduction of alcohol intake was maintained for 5 consecutive days by daily prazosin treatment in the subsequent more prolonged trial (

…

RESULTS: Prazosin significantly reduced (p < 0.01) alcohol intake during the initial 2 daily administrations, and this redu

…
Factors impacting prazosin efficacy for nightmares and insomnia in PTSD patients - a systematic review and meta-regression analysis.
Mendes TP, Pereira BG, Coutinho ESF, Melani MS, Neylan TC, Berger W. Mendes TP, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111253. doi: 10.1016/j.pnpbp.2025.111253. Epub 2025 Jan 17. Prog Neuropsychopharmacol Biol Psychiatry. 2025. PMID: 39828080
Ten RCTs with 648 patients were included. Analysis revealed prazosin significantly improved insomnia (SMD = -0.654, p = 0.043) and nightmares (SMD = -0.641, p = 0.025), but not overall PTSD symptoms (SMD = -0.428, p = 0.077). ...Benzodiazepine co-admin …
Ten RCTs with 648 patients were included. Analysis revealed prazosin significantly improved insomnia (SMD = -0.654, p = 0.043) …
A randomized controlled clinical trial of prazosin for alcohol use disorder in active duty soldiers: Predictive effects of elevated cardiovascular parameters.
Raskind MA, Williams T, Holmes H, Hart K, Crews L, Poupore EL, Thomas RG, Darnell J, Daniels C, Goke K, Hendrickson R, Terry G, Mayer C, Simpson T, Saxon A, Rasmussen D, Peskind ER. Raskind MA, et al. Alcohol Clin Exp Res (Hoboken). 2023 Feb;47(2):348-360. doi: 10.1111/acer.14989. Epub 2023 Feb 21. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 36809662 Clinical Trial.
In soldiers with elevated standing heart rate (n = 15), prazosin reduced SDUs per day (p = 0.01), % days drinking (p = 0.03), and % days heavy drinking (p = 0.001) relative to placebo. ...Prazosin also reduced depressive symptoms and the inciden …
In soldiers with elevated standing heart rate (n = 15), prazosin reduced SDUs per day (p = 0.01), % days drinking (p = …
The cytotoxicity of the alpha1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P.
Fuchs R, Stracke A, Ebner N, Zeller CW, Raninger AM, Schittmayer M, Kueznik T, Absenger-Novak M, Birner-Gruenberger R. Fuchs R, et al. Toxicology. 2015 Dec 2;338:17-29. doi: 10.1016/j.tox.2015.09.008. Epub 2015 Oct 9. Toxicology. 2015. PMID: 26449523 Free PMC article.
Besides inducing apoptosis, PRZ was shown to serve as a substrate for an amine uptake mechanism originally discovered in neurones called transport-P. In line with our hypothesis that transport-P is an endocytotic mechanism also present in non-neuronal tissue and lin …
Besides inducing apoptosis, PRZ was shown to serve as a substrate for an amine uptake mechanism originally discovered in neurones called tra …
Effect of prazosin on feline recurrent urethral obstruction.
Hanson KR, Rudloff E, Yuan L, Mochel JP, Linklater AK. Hanson KR, et al. J Feline Med Surg. 2021 Dec;23(12):1176-1182. doi: 10.1177/1098612X211001283. Epub 2021 Mar 22. J Feline Med Surg. 2021. PMID: 33749375 Free PMC article.
There was no significant difference in frequency of rUO in cats treated with prazosin vs placebo (P = 0.27). CONCLUSIONS AND RELEVANCE: Prazosin administered at 0.5 mg PO q12h did not decrease the rate of rUO in this population of obstructed male cats vs plac …
There was no significant difference in frequency of rUO in cats treated with prazosin vs placebo (P = 0.27). CONCLUSIONS AND R …
Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin.
Simon PY, Rousseau PF. Simon PY, et al. Can J Psychiatry. 2017 Mar;62(3):186-198. doi: 10.1177/0706743716659275. Epub 2016 Jul 19. Can J Psychiatry. 2017. PMID: 27432823 Free PMC article.
To be considered for inclusion, studies had to test the efficacy of prazosin either alone or added to ongoing treatment in adults with PTSD, use validated tools to assess and monitor the disorders, allow comparisons on the basis of univariate analyses (i.e., p-value …
To be considered for inclusion, studies had to test the efficacy of prazosin either alone or added to ongoing treatment in adults wit …
Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse.
Froehlich JC, Hausauer B, Fischer S, Wise B, Rasmussen DD. Froehlich JC, et al. Alcohol Clin Exp Res. 2015 Aug;39(8):1538-46. doi: 10.1111/acer.12789. Alcohol Clin Exp Res. 2015. PMID: 26207767 Free PMC article.
This study explores whether prazosin prevents alcohol "relapse" in P rats, as reflected by a reduced or abolished ADE. ...CONCLUSIONS: Prazosin decreases alcohol intake in P rats even in a situation that would be expected to increase alcohol drinking, …
This study explores whether prazosin prevents alcohol "relapse" in P rats, as reflected by a reduced or abolished ADE. ...CONC …
Comparative efficacy of imagery rehearsal therapy and prazosin in the treatment of trauma-related nightmares in adults: A meta-analysis of randomized controlled trials.
Yücel DE, van Emmerik AAP, Souama C, Lancee J. Yücel DE, et al. Sleep Med Rev. 2020 Apr;50:101248. doi: 10.1016/j.smrv.2019.101248. Epub 2019 Nov 28. Sleep Med Rev. 2020. PMID: 31855732 Review.
Eight studies on IRT and seven studies on prazosin (N = 1.078) were analyzed based on the random effects model. Relative to control groups, prazosin had a moderate to large effect on nightmare frequency (g = 0.61), posttraumatic stress symptoms (g = 0.81), and sleep …
Eight studies on IRT and seven studies on prazosin (N = 1.078) were analyzed based on the random effects model. Relative to control g …
Search for the pharmacophore in prazosin for Transport-P.
Zunszain PA, Federico C, Sechi M, Al-Damluji S, Ganellin CR. Zunszain PA, et al. Bioorg Med Chem. 2005 Jun 1;13(11):3681-9. doi: 10.1016/j.bmc.2005.03.030. Bioorg Med Chem. 2005. PMID: 15862997
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. ...
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structu …
4,587 results