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Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
Brown AA, Fernandez-Tajes JJ, Hong MG, Brorsson CA, Koivula RW, Davtian D, Dupuis T, Sartori A, Michalettou TD, Forgie IM, Adam J, Allin KH, Caiazzo R, Cederberg H, De Masi F, Elders PJM, Giordano GN, Haid M, Hansen T, Hansen TH, Hattersley AT, Heggie AJ, Howald C, Jones AG, Kokkola T, Laakso M, Mahajan A, Mari A, McDonald TJ, McEvoy D, Mourby M, Musholt PB, Nilsson B, Pattou F, Penet D, Raverdy V, Ridderstråle M, Romano L, Rutters F, Sharma S, Teare H, 't Hart L, Tsirigos KD, Vangipurapu J, Vestergaard H, Brunak S, Franks PW, Frost G, Grallert H, Jablonka B, McCarthy MI, Pavo I, Pedersen O, Ruetten H, Walker M; DIRECT Consortium; Adamski J, Schwenk JM, Pearson ER, Dermitzakis ET, Viñuela A. Brown AA, et al. Nat Commun. 2023 Aug 21;14(1):5062. doi: 10.1038/s41467-023-40569-3. Nat Commun. 2023. PMID: 37604891 Free PMC article.
The influence of metformin treatment on the circulating proteome.
Connolly B, McCreight L, Slieker RC, Bedair KF, Donnelly L, de Klerk JA, Beulens JWJ, Elders PJM, Bergström G, Hong MG, Koivula RW, Franks PW, Schwenk JM, Gummesson A, Pearson ER, 't Hart LM; IMI-DIRECT; IMI-RHAPSODY. Connolly B, et al. EBioMedicine. 2025 Aug;118:105859. doi: 10.1016/j.ebiom.2025.105859. Epub 2025 Jul 19. EBioMedicine. 2025. PMID: 40684475 Free PMC article.