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Page 1
Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy.
Desai MY, Owens AT, Abraham T, Olivotto I, Garcia-Pavia P, Lopes RD, Elliott P, Fernandes F, Verheyen N, Maier L, Meder B, Azevedo O, Kitaoka H, Wolski K, Wang Q, Jaber W, Mitchell L, Myers J, Rano T, Gong Z, Zhong Y, Carter-Bonanza S, Florea V, Aronson R, Nissen SE; ODYSSEY-HCM Investigators. Desai MY, et al. Among authors: rano t. N Engl J Med. 2025 Sep 11;393(10):961-972. doi: 10.1056/NEJMoa2505927. Epub 2025 Aug 30. N Engl J Med. 2025. PMID: 40888717 Clinical Trial.
Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Design, Rationale, and Baseline Characteristics of ODYSSEY-HCM.
Desai MY, Nissen SE, Abraham T, Olivotto I, Garcia-Pavia P, Lopes RD, Verheyen N, Wever-Pinzon O, Wolski K, Jaber W, Mitchell L, Davey D, Myers J, Rano T, Bhatia V, Zhong Y, Carter-Bonanza S, Florea V, Aronson R, Owens AT; ODYSSEY-HCM Investigators. Desai MY, et al. Among authors: rano t. JACC Heart Fail. 2025 Feb;13(2):358-370. doi: 10.1016/j.jchf.2024.11.013. JACC Heart Fail. 2025. PMID: 39909647 Free article.
Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.
Kuo GH, Rano T, Pelton P, Demarest KT, Gibbs AC, Murray WV, Damiano BP, Connelly MA. Kuo GH, et al. Among authors: rano t. J Med Chem. 2009 Mar 26;52(6):1768-72. doi: 10.1021/jm801319d. J Med Chem. 2009. PMID: 19236017
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.
Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW. Thornberry NA, et al. Among authors: rano ta. J Biol Chem. 1997 Jul 18;272(29):17907-11. doi: 10.1074/jbc.272.29.17907. J Biol Chem. 1997. PMID: 9218414 Free article.
A combinatorial library of indinavir analogues and its in vitro and in vivo studies.
Cheng Y, Rano TA, Huening TT, Zhang F, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Lin JH, Xu X, Jin L, Olah TV, McLoughlin DA, King RC, Chapman KT, Tata JR. Cheng Y, et al. Among authors: rano ta. Bioorg Med Chem Lett. 2002 Feb 25;12(4):529-32. doi: 10.1016/s0960-894x(01)00824-1. Bioorg Med Chem Lett. 2002. PMID: 11844665
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