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. 2023 Mar 27;13(3):e066909.
doi: 10.1136/bmjopen-2022-066909.

Cohort profile - the Renal cell cancer: Lifestyle, prognosis and quality of life (ReLife) study in the Netherlands

Jake S F Maurits  1 , J P Michiel Sedelaar  2 , Katja K H Aben  1   3 , Ellen Kampman  1   4 ; ReLife study group; Lambertus A L M Kiemeney  1 , Alina Vrieling  5
Collaborators, Affiliations

Cohort profile - the Renal cell cancer: Lifestyle, prognosis and quality of life (ReLife) study in the Netherlands

Jake S F Maurits et al. BMJ Open. .

Abstract

Purpose: The Renal cell cancer: Lifestyle, prognosis and quality of life (ReLife) study is set up to obtain insight into the association of patient and tumour characteristics, lifestyle habits and circulating biomarkers with body composition features in patients with localised renal cell cancer (RCC). Further, it aims to assess the association of body composition features, lifestyle habits and circulating biomarkers with clinical outcomes, including health-related quality of life.

Participants: The ReLife study is a multicentre prospective cohort study involving 368 patients with newly diagnosed stages I-III RCC recruited from January 2018 to June 2021 from 18 hospitals in the Netherlands. At 3 months, 1 year and 2 years after treatment, participants fill out a general questionnaire and questionnaires about their lifestyle habits (eg, diet, physical activity, smoking and alcohol consumption), medical history and health-related quality of life. At all three time points, patients wear an accelerometer and have blood samples taken. CT scans for body composition analysis are being collected. Permission is asked for collection of tumour samples. Information about disease characteristics, treatment of the primary tumour and clinical outcomes is being collected from medical records by the Netherlands Cancer Registry.

Findings to date: A total of 836 invited patients were eligible and 368 patients were willing to participate and were included (response rate 44%). The mean age of patients was 62.5±9.0 years and 70% was male. The majority had stage I (65%) disease and were treated with radical nephrectomy (57%). Data collection at 3 months and 1 years after treatment have been finalised.

Future plans: Data collection at 2 years after treatment is expected to be finalised in June 2023 and longitudinal clinical data will continue to be collected. Results of studies based on this cohort are important to develop personalised evidence-based lifestyle advice for patients with localised RCC to enable them to get more control over their disease course.

Keywords: Epidemiology; Kidney tumours; NUTRITION & DIETETICS; PREVENTIVE MEDICINE.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Timeline and study design of the ReLife study. ReLife, Renal cell cancer: Lifestyle, prognosis and quality of life.
Figure 2
Figure 2
Flowchart of the ReLife study. ReLife, Renal cell cancer: Lifestyle, prognosis and quality of life.
See this image and copyright information in PMC

References

    1. Capitanio U, Bensalah K, Bex A, et al. . Epidemiology of renal cell carcinoma. Eur Urol 2019;75:74–84. 10.1016/j.eururo.2018.08.036 - DOI - PMC - PubMed
    1. van de Schans SAM, Aben KKH, Mulders PFA, et al. . Modest improvement in 20 years of kidney cancer care in the Netherlands. Eur J Cancer 2012;48:1822–30. 10.1016/j.ejca.2012.01.033 - DOI - PubMed
    1. Sung H, Ferlay J, Siegel RL, et al. . Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209–49. 10.3322/caac.21660 - DOI - PubMed
    1. Netherlands Cancer Registry (NCR), Netherlands Comprehensive Cancer Organisation (IKNL). 2023. Available: www.iknl.nl/en/ncr/ncr-data-figures
    1. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol 2010;7:245–57. 10.1038/nrurol.2010.46 - DOI - PMC - PubMed

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