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90 results

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Page 1
Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma.
Fandrei D, Seiffert S, Rade M, Rieprecht S, Gagelmann N, Born P, Wiemers T, Weidner H, Kreuz M, Schassberger T, Koßmann J, Mangold M, Fürst D, Fischer L, Baber R, Heyn S, Wang SY, Bach E, Hoffmann S, Metzeler KH, Herling M, Jentzsch M, Franke GN, Köhl U, Friedrich M, Boldt A, Reiche K, Platzbecker U, Vucinic V, Merz M. Fandrei D, et al. Among authors: reiche k. Blood Cancer Discov. 2025 Jan 8;6(1):38-54. doi: 10.1158/2643-3230.BCD-24-0118. Blood Cancer Discov. 2025. PMID: 39441177 Free PMC article.
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma.
Rade M, Grieb N, Weiss R, Sia J, Fischer L, Born P, Boldt A, Fricke S, Franz P, Scolnick J, Venkatraman L, Xu S, Kloetzer C, Heyn S, Kubasch AS, Baber R, Wang SY, Bach E, Hoffmann S, Ussmann J, Schetschorke B, Hell S, Schwind S, Metzeler KH, Herling M, Jentzsch M, Franke GN, Sack U, Köhl U, Platzbecker U, Reiche K, Vucinic V, Merz M. Rade M, et al. Among authors: reiche k. Nat Cancer. 2024 Sep;5(9):1318-1333. doi: 10.1038/s43018-024-00763-8. Epub 2024 Apr 19. Nat Cancer. 2024. PMID: 38641734
Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody.
Braun T, Rade M, Merz M, Klepzig H, Große F, Fandrei D, Pham NN, Kreuz M, Kuhn CK, Kuschel F, Löffler D, Meinel J, Heger E, Schweinsberg V, Pflug N, Platzbecker U, Hallek M, Holtick U, Köhl U, Scheid C, Reiche K, Herling M, Richardson T. Braun T, et al. Among authors: reiche k. Nat Med. 2025 Apr;31(4):1145-1153. doi: 10.1038/s41591-025-03499-9. Epub 2025 Feb 21. Nat Med. 2025. PMID: 39984633
Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS); Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI); Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL. Warnat-Herresthal S, et al. Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26. Nature. 2021. PMID: 34040261 Free PMC article.
Community assessment of methods to deconvolve cellular composition from bulk gene expression.
White BS, de Reyniès A, Newman AM, Waterfall JJ, Lamb A, Petitprez F, Lin Y, Yu R, Guerrero-Gimenez ME, Domanskyi S, Monaco G, Chung V, Banerjee J, Derrick D, Valdeolivas A, Li H, Xiao X, Wang S, Zheng F, Yang W, Catania CA, Lang BJ, Bertus TJ, Piermarocchi C, Caruso FP, Ceccarelli M, Yu T, Guo X, Bletz J, Coller J, Maecker H, Duault C, Shokoohi V, Patel S, Liliental JE, Simon S; Tumor Deconvolution DREAM Challenge consortium; Saez-Rodriguez J, Heiser LM, Guinney J, Gentles AJ. White BS, et al. Nat Commun. 2024 Aug 27;15(1):7362. doi: 10.1038/s41467-024-50618-0. Nat Commun. 2024. PMID: 39191725 Free PMC article.
Immune digital twins for complex human pathologies: applications, limitations, and challenges.
Niarakis A, Laubenbacher R, An G, Ilan Y, Fisher J, Flobak Å, Reiche K, Rodríguez Martínez M, Geris L, Ladeira L, Veschini L, Blinov ML, Messina F, Fonseca LL, Ferreira S, Montagud A, Noël V, Marku M, Tsirvouli E, Torres MM, Harris LA, Sego TJ, Cockrell C, Shick AE, Balci H, Salazar A, Rian K, Hemedan AA, Esteban-Medina M, Staumont B, Hernandez-Vargas E, Martis B S, Madrid-Valiente A, Karampelesis P, Sordo Vieira L, Harlapur P, Kulesza A, Nikaein N, Garira W, Malik Sheriff RS, Thakar J, Tran VDT, Carbonell-Caballero J, Safaei S, Valencia A, Zinovyev A, Glazier JA. Niarakis A, et al. Among authors: reiche k. NPJ Syst Biol Appl. 2024 Nov 30;10(1):141. doi: 10.1038/s41540-024-00450-5. NPJ Syst Biol Appl. 2024. PMID: 39616158 Free PMC article. Review.
Emerging T-cell lymphomas after CAR T-cell therapy.
Braun T, Kuschel F, Reiche K, Merz M, Herling M. Braun T, et al. Among authors: reiche k. Leukemia. 2025 Jun;39(6):1337-1341. doi: 10.1038/s41375-025-02574-x. Epub 2025 Apr 7. Leukemia. 2025. PMID: 40195525 Free PMC article. Review. No abstract available.
Virtual twins for personalised CAR T-cell therapy in myeloma.
Reiche K, Weirauch U, Kreuz M, Fischer L, Gras L, Neumuth T, Platzbecker U, Köhl U, Demlova R, Kremer A, Fröhlich H, Franke S, Merz M; CERTAINTY Consortium. Reiche K, et al. Lancet Haematol. 2025 Jul;12(7):e490-e491. doi: 10.1016/S2352-3026(25)00170-X. Lancet Haematol. 2025. PMID: 40610172 No abstract available.
Alzheimer-related genes show accelerated evolution.
Nitsche A, Arnold C, Ueberham U, Reiche K, Fallmann J, Hackermüller J, Horn F, Stadler PF, Arendt T. Nitsche A, et al. Among authors: reiche k. Mol Psychiatry. 2021 Oct;26(10):5790-5796. doi: 10.1038/s41380-020-0680-1. Epub 2020 Mar 13. Mol Psychiatry. 2021. PMID: 32203153 Free PMC article.
ROR2-specific CAR T cells are effective against hematologic and solid tumors and well tolerated in mice.
Weber J, Rade M, Michael J, Tony LT, Freitag F, Spieler P, Müller C, Kalogirou C, Mainz L, Lehmann J, Klopfleisch R, Rosenfeldt MT, Danhof S, Kortüm KM, Köhl U, Einsele H, Rader C, Reiche K, Nerreter T, Hudecek M. Weber J, et al. Among authors: reiche k. Cell Rep Med. 2025 Oct 21;6(10):102400. doi: 10.1016/j.xcrm.2025.102400. Epub 2025 Oct 6. Cell Rep Med. 2025. PMID: 41056951 Free article.
90 results