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. 1991 Sep;11(9):4679-89.
doi: 10.1128/mcb.11.9.4679-4689.1991.

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

A P Jarman  1 , W G Wood, J A Sharpe, G Gourdon, H Ayyub, D R Higgs
Affiliations

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

A P Jarman et al. Mol Cell Biol. 1991 Sep.

Abstract

The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta 2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression.

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