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2010 5832
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97,408 results

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Page 1
Showing results for same n
Search for Samer N instead (1 results)
S-adenosylmethionine in liver health, injury, and cancer.
Lu SC, Mato JM. Lu SC, et al. Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011. Physiol Rev. 2012. PMID: 23073625 Free PMC article. Review.
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. ...This can result from inactive mutation of the enzyme glycine N-methyltransferase (GNMT). …
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalia …
Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting.
Capelo-Diz A, Lachiondo-Ortega S, Fernández-Ramos D, Cañas-Martín J, Goikoetxea-Usandizaga N, Serrano-Maciá M, González-Rellan MJ, Mosca L, Blazquez-Vicens J, Tinahones-Ruano A, Fondevila MF, Buyan M, Delgado TC, Gutierrez de Juan V, Ayuso-García P, Sánchez-Rueda A, Velasco-Avilés S, Fernández-Susavila H, Riobello-Suárez C, Dziechciarz B, Montiel-Duarte C, Lopitz-Otsoa F, Bizkarguenaga M, Bilbao-García J, Bernardo-Seisdedos G, Senra A, Soriano-Navarro M, Millet O, Díaz-Lagares Á, Crujeiras AB, Bao-Caamano A, Cabrera D, van Liempd S, Tamayo-Carro M, Borzacchiello L, Gomez-Santos B, Buqué X, Sáenz de Urturi D, González-Romero F, Simon J, Rodríguez-Agudo R, Ruiz A, Matute C, Beiroa D, Falcon-Perez JM, Aspichueta P, Rodríguez-Cuesta J, Porcelli M, Pajares MA, Ameneiro C, Fidalgo M, Aransay AM, Lama-Díaz T, Blanco MG, López M, Villa-Bellosta R, Müller TD, Nogueiras R, Woodhoo A, Martínez-Chantar ML, Varela-Rey M. Capelo-Diz A, et al. Cell Metab. 2023 Aug 8;35(8):1373-1389.e8. doi: 10.1016/j.cmet.2023.07.002. Epub 2023 Jul 31. Cell Metab. 2023. PMID: 37527658 Free PMC article.
There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major organs of the body. Here, we show that in mice, hepatic S-adenosylmethionine (SAMe)-the principal methyl donor-acts as a metabo …
There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major o …
Radical S-adenosylmethionine enzymes.
Broderick JB, Duffus BR, Duschene KS, Shepard EM. Broderick JB, et al. Chem Rev. 2014 Apr 23;114(8):4229-317. doi: 10.1021/cr4004709. Epub 2014 Jan 29. Chem Rev. 2014. PMID: 24476342 Free PMC article. Review. No abstract available.
Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target.
Gao Y, Martin NI, van Haren MJ. Gao Y, et al. Drug Discov Today. 2021 Nov;26(11):2699-2706. doi: 10.1016/j.drudis.2021.05.011. Epub 2021 May 21. Drug Discov Today. 2021. PMID: 34029690 Free article. Review.
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (NA) to generate 1-methyl nicotinamide. ...
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (NA) to generate 1-methyl nicotinamide. ...
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.
Terneus MV, Brown JM, Carpenter AB, Valentovic MA. Terneus MV, et al. Toxicology. 2008 Feb 3;244(1):25-34. doi: 10.1016/j.tox.2007.10.027. Epub 2007 Nov 7. Toxicology. 2008. PMID: 18068290 Free PMC article.
Comparisons were made for potency between SAMe and N-acetylcysteine (NAC), the current treatment for APAP toxicity. Male C57BL/6 mice were fasted overnight and divided into groups: control (VEH), SAMe treated (SAMe), APAP treated (APAP), N-acetylcysteine treated (NA …
Comparisons were made for potency between SAMe and N-acetylcysteine (NAC), the current treatment for APAP toxicity. Male C57BL/6 mice …
SAMe and sexual functioning.
Dording CM, Mischoulon D, Shyu I, Alpert JE, Papakostas GI. Dording CM, et al. Eur Psychiatry. 2012 Aug;27(6):451-4. doi: 10.1016/j.eurpsy.2011.01.003. Epub 2011 Mar 12. Eur Psychiatry. 2012. PMID: 21398094 Clinical Trial.
Enzymatic Cascade Reactions in Biosynthesis.
Walsh CT, Moore BS. Walsh CT, et al. Angew Chem Int Ed Engl. 2019 May 20;58(21):6846-6879. doi: 10.1002/anie.201807844. Epub 2019 Feb 20. Angew Chem Int Ed Engl. 2019. PMID: 30156048 Free PMC article. Review.
At anaerobic end, enzymes reversibly cleave S-adenosylmethionine (SAM) to generate the 5'-deoxyadenosyl radical as a powerful oxidant to initiate C-H bond homolysis in bound substrates. ...
At anaerobic end, enzymes reversibly cleave S-adenosylmethionine (SAM) to generate the 5'-deoxyadenosyl radical as a powerful …
Kinetic Mechanism of Nicotinamide N-Methyltransferase.
Loring HS, Thompson PR. Loring HS, et al. Biochemistry. 2018 Sep 25;57(38):5524-5532. doi: 10.1021/acs.biochem.8b00775. Epub 2018 Sep 10. Biochemistry. 2018. PMID: 30148963
Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. ...
Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nic …
Chemical probes for protein arginine methyltransferases.
Li ASM, Li F, Eram MS, Bolotokova A, Dela Seña CC, Vedadi M. Li ASM, et al. Methods. 2020 Mar 15;175:30-43. doi: 10.1016/j.ymeth.2019.11.017. Epub 2019 Dec 3. Methods. 2020. PMID: 31809836 Review.
Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to specific arginine residues of their substrates using S-adenosylmethionine as a methyl donor, contributing to regulation of many biological processes including transcription, and DN …
Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to specific arginine residues of their substrates using …
The complex role of glycine N-methyltransferase in metabolism-a review.
Suzauddula M, Islam MN, Ahmed T. Suzauddula M, et al. Mol Biol Rep. 2025 Mar 1;52(1):271. doi: 10.1007/s11033-025-10374-w. Mol Biol Rep. 2025. PMID: 40025311 Review.
Deletion or Knockdown of GNMT influences the expression of several key metabolic enzymes by accumulating S-adenosylmethionine (SAM). Dysregulation of GNMT and these metabolic enzymes can lead to metabolic dysfunction and chronic diseases. ...Current understanding su …
Deletion or Knockdown of GNMT influences the expression of several key metabolic enzymes by accumulating S-adenosylmethionine …
97,408 results
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