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Year Number of Results
2001 1
2002 3
2003 3
2004 4
2005 4
2006 1
2007 6
2008 4
2009 12
2010 8
2011 10
2012 6
2013 9
2014 6
2015 12
2016 13
2017 6
2018 11
2019 14
2020 4
2021 4
2022 7
2023 4
2024 3
2025 2

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143 results

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Page 1
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S. Patel S, et al. Among authors: savage db. Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10. Cell Metab. 2019. PMID: 30639358 Free PMC article.
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van de Bunt M, Gaulton KJ, Eicher JD, Sharp SJ, Luan J, De Lucia Rolfe E, Stewart ID, Wheeler E, Willems SM, Adams C, Yaghootkar H; EPIC-InterAct Consortium; Cambridge FPLD1 Consortium; Forouhi NG, Khaw KT, Johnson AD, Semple RK, Frayling T, Perry JR, Dermitzakis E, McCarthy MI, Barroso I, Wareham NJ, Savage DB, Langenberg C, O'Rahilly S, Scott RA. Lotta LA, et al. Among authors: savage db. Nat Genet. 2017 Jan;49(1):17-26. doi: 10.1038/ng.3714. Epub 2016 Nov 14. Nat Genet. 2017. PMID: 27841877 Free PMC article.
GDF15 mediates the effects of metformin on body weight and energy balance.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S. Coll AP, et al. Among authors: savage db. Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25. Nature. 2020. PMID: 31875646 Free PMC article. Clinical Trial.
MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT.
Ninni A, Zaccaria F, Verteramo L, Sciarretta F, Silveira LS, Rosa-Neto JC, Carotti S, Nevi L, Grumati P, Patel S, Carrera G, Sgambato A, Lucchetti D, Colella F, Severi I, Senzacqua M, Giordano A, Bernardini S, Di Biagio C, Tortolici F, Rizzo G, Cochain C, Chiurchiù V, Ivanov S, Zhou B, Williams JW, Savage DB, Aquilano K, Lettieri-Barbato D. Ninni A, et al. Among authors: savage db. Nat Commun. 2025 May 31;16(1):5063. doi: 10.1038/s41467-025-60295-2. Nat Commun. 2025. PMID: 40450001 Free PMC article.
Recent developments in lipodystrophy.
Melvin A, Stears A, Savage DB. Melvin A, et al. Among authors: savage db. Curr Opin Lipidol. 2019 Aug;30(4):284-290. doi: 10.1097/MOL.0000000000000613. Curr Opin Lipidol. 2019. PMID: 31135595 Review.
Genetic syndromes of severe insulin resistance.
Melvin A, O'Rahilly S, Savage DB. Melvin A, et al. Among authors: savage db. Curr Opin Genet Dev. 2018 Jun;50:60-67. doi: 10.1016/j.gde.2018.02.002. Epub 2018 Feb 22. Curr Opin Genet Dev. 2018. PMID: 29477938 Review.
What lipodystrophies teach us about the metabolic syndrome.
Mann JP, Savage DB. Mann JP, et al. Among authors: savage db. J Clin Invest. 2019 Aug 5;129(10):4009-4021. doi: 10.1172/JCI129190. eCollection 2019 Aug 5. J Clin Invest. 2019. PMID: 31380809 Free PMC article. Review.
Loss of Mfn1 but not Mfn2 enhances adipogenesis.
Mann JP, Tábara LC, Patel S, Pushpa P, Alvarez-Guaita A, Dong L, Haider A, Lim K, Tandon P, Scurria F, Minchin JEN, O'Rahilly S S, Fazakerley DJ, Prudent J, Semple RK, Savage DB. Mann JP, et al. Among authors: savage db. PLoS One. 2024 Dec 31;19(12):e0306243. doi: 10.1371/journal.pone.0306243. eCollection 2024. PLoS One. 2024. PMID: 39739772 Free PMC article.
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation.
Zeng Q, Patel S, Wang X, Hsieh MH, Li Z, Ren X, Wang J, Kim D, Li S, Gu X, Mannino G, Maggiore G, Fang X, Li L, Zhu M, Wang M, Li B, Bellary A, Lim K, Qi Z, Pushpa P, Mandour MO, Saudek V, Sharma T, Zhang Y, Hoxhaj G, Mishra P, Gopal P, Campbell P, Hoare M, Savage DB, Zhu H. Zeng Q, et al. Among authors: savage db. J Hepatol. 2025 Jul 4:S0168-8278(25)02320-7. doi: 10.1016/j.jhep.2025.06.021. Online ahead of print. J Hepatol. 2025. PMID: 40618957 Free PMC article.
The genetics of lipid storage and human lipodystrophies.
Robbins AL, Savage DB. Robbins AL, et al. Among authors: savage db. Trends Mol Med. 2015 Jul;21(7):433-8. doi: 10.1016/j.molmed.2015.04.004. Epub 2015 May 12. Trends Mol Med. 2015. PMID: 25979754 Review.
143 results