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Year Number of Results
2000 2
2001 4
2002 3
2004 3
2005 2
2006 4
2007 8
2008 5
2009 4
2010 9
2011 10
2012 8
2013 9
2014 7
2015 5
2016 10
2017 4
2018 1
2019 8
2020 6
2021 9
2022 10
2023 12
2024 17
2025 12

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156 results

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Page 1
Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias.
Kwon MC, Thuring JW, Querolle O, Dai X, Verhulst T, Pande V, Marien A, Goffin D, Wenge DV, Yue H, Cutler JA, Jin C, Perner F, Hogeling SM, Shaffer PL, Jacobs F, Vinken P, Cai W, Keersmaekers V, Eyassu F, Bhogal B, Verstraeten K, El Ashkar S, Perry JA, Jayaguru P, Barreyro L, Kuchnio A, Darville N, Krosky D, Urbanietz G, Verbist B, Edwards JP, Cowley GS, Kirkpatrick R, Steele R, Ferrante L, Guttke C, Daskalakis N, Pietsch EC, Wilson DM, Attar R, Elsayed Y, Fischer ES, Schuringa JJ, Armstrong SA, Packman K, Philippar U. Kwon MC, et al. Among authors: schuringa jj. Blood. 2024 Sep 12;144(11):1206-1220. doi: 10.1182/blood.2023022480. Blood. 2024. PMID: 38905635 Free PMC article.
M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism.
Weinhäuser I, Pereira-Martins DA, Almeida LY, Hilberink JR, Silveira DRA, Quek L, Ortiz C, Araujo CL, Bianco TM, Lucena-Araujo A, Mota JM, Hogeling SM, Sternadt D, Visser N, Diepstra A, Ammatuna E, Huls G, Rego EM, Schuringa JJ. Weinhäuser I, et al. Among authors: schuringa jj. Sci Adv. 2023 Apr 14;9(15):eadf8522. doi: 10.1126/sciadv.adf8522. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058562 Free PMC article.
The EHA Research Roadmap: Normal Hematopoiesis.
Jaffredo T, Balduini A, Bigas A, Bernardi R, Bonnet D, Canque B, Charbord P, Cumano A, Delwel R, Durand C, Fibbe W, Forrester L, de Franceschi L, Ghevaert C, Gjertsen B, Gottgens B, Graf T, Heidenreich O, Hermine O, Higgs D, Kleanthous M, Klump H, Kouskoff V, Krause D, Lacaud G, Celso CL, Martens JHA, Méndez-Ferrer S, Menendez P, Oostendorp R, Philipsen S, Porse B, Raaijmakers M, Robin C, Stunnenberg H, Theilgaard-Mönch K, Touw I, Vainchenker W, Corrons JV, Yvernogeau L, Schuringa JJ. Jaffredo T, et al. Among authors: schuringa jj. Hemasphere. 2021 Nov 30;5(12):e669. doi: 10.1097/HS9.0000000000000669. eCollection 2021 Dec. Hemasphere. 2021. PMID: 34853826 Free PMC article. No abstract available.
Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia.
Hogeling SM, Lê DM, La Rose N, Kwon MC, Wierenga ATJ, Van den Heuvel FAJ, Van den Boom V, Kuchnio A, Philippar U, Huls G, Schuringa JJ. Hogeling SM, et al. Among authors: schuringa jj. Haematologica. 2025 Jun 1;110(6):1278-1291. doi: 10.3324/haematol.2024.285616. Epub 2024 Dec 19. Haematologica. 2025. PMID: 39704147 Free PMC article.
Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold.
Griessinger E, Pereira-Martins D, Nebout M, Bosc C, Saland E, Boet E, Sahal A, Chiche J, Debayle D, Fleuriot L, Pruis M, De Mas V, Vergez F, Récher C, Huls G, Sarry JE, Schuringa JJ, Peyron JF. Griessinger E, et al. Among authors: schuringa jj. Cancer Res. 2023 Aug 1;83(15):2461-2470. doi: 10.1158/0008-5472.CAN-23-1006. Cancer Res. 2023. PMID: 37272750 Free PMC article.
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation.
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J, Wang LM, Campos J, Magee AMS, Woodley K, Austin MJ, Rio-Machin A, Casado P, Bewicke-Copley F, Rodriguez Blanco G, Pereira-Martins D, Oudejans L, Boet E, von Kriegsheim A, Schwaller J, Finch AJ, Patel B, Sarry JE, Tamburini J, Schuringa JJ, Hazlehurst L, Copland Iii JA, Yuneva M, Peck B, Cutillas P, Fitzgibbon J, Rouault-Pierre K, Kranc K, Gallipoli P. Dembitz V, et al. Among authors: schuringa jj. Leukemia. 2024 Nov;38(11):2395-2409. doi: 10.1038/s41375-024-02390-9. Epub 2024 Aug 26. Leukemia. 2024. PMID: 39187579 Free PMC article.
PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.
Alshamleh I, Kurrle N, Makowka P, Bhayadia R, Kumar R, Süsser S, Seibert M, Ludig D, Wolf S, Koschade SE, Stoschek K, Kreitz J, Fuhrmann DC, Toenges R, Notaro M, Comoglio F, Schuringa JJ, Berg T, Brüne B, Krause DS, Klusmann JH, Oellerich T, Schnütgen F, Schwalbe H, Serve H. Alshamleh I, et al. Among authors: schuringa jj. Leukemia. 2023 Dec;37(12):2367-2382. doi: 10.1038/s41375-023-02041-5. Epub 2023 Nov 7. Leukemia. 2023. PMID: 37935978 Free PMC article.
Clonal hematopoiesis and myeloid skewing in older population-based individuals.
van Bergen MGJM, Kamphuis P, de Graaf AO, Salzbrunn JB, Koorenhof-Scheele TN, van Zeventer IA, Dinmohamed AG, Schuringa JJ, van der Reijden BA, Huls G, Jansen JH. van Bergen MGJM, et al. Among authors: schuringa jj. Am J Hematol. 2024 Dec;99(12):2402-2405. doi: 10.1002/ajh.27495. Epub 2024 Oct 21. Am J Hematol. 2024. PMID: 39429216 No abstract available.
156 results