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Page 1
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial.
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A, Fossati-Jimack L, Thorborn G, Ahmed M, Prediletto E, Church SE, Hudson BM, Warren SE, McKeigue PM, Humby F, Bombardieri M, Barnes MR, Lewis MJ, Pitzalis C; R4RA collaborative group. Rivellese F, et al. Among authors: sciacca e. Nat Med. 2022 Jun;28(6):1256-1268. doi: 10.1038/s41591-022-01789-0. Epub 2022 May 19. Nat Med. 2022. PMID: 35589854 Free PMC article. Clinical Trial.
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin MB, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ, Nourshargh S. Rolas L, et al. Among authors: sciacca e. EMBO Rep. 2024 Sep;25(9):3842-3869. doi: 10.1038/s44319-024-00182-x. Epub 2024 Jun 25. EMBO Rep. 2024. PMID: 38918502 Free PMC article.
C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation.
Veschi V, Verona F, Di Bella S, Turdo A, Gaggianesi M, Di Franco S, Mangiapane LR, Modica C, Lo Iacono M, Bianca P, Brancato OR, D'Accardo C, Porcelli G, Lentini VL, Sperduti I, Sciacca E, Fitzgerald P, Lopez-Perez D, Martine P, Brown K, Giannini G, Appella E, Stassi G, Todaro M. Veschi V, et al. Among authors: sciacca e. Mol Cancer. 2025 Mar 31;24(1):102. doi: 10.1186/s12943-025-02293-y. Mol Cancer. 2025. PMID: 40165182 Free PMC article.
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E, Abatecola F, Caliste M, Pagani S, Mauro D, Bellan M, Cubuk C, Lau R, Church SE, Hudson BM, Humby F, Bombardieri M, Lewis MJ, Pitzalis C. Nerviani A, et al. Among authors: sciacca e. Nat Commun. 2024 Mar 16;15(1):2398. doi: 10.1038/s41467-024-46564-6. Nat Commun. 2024. PMID: 38493215 Free PMC article.
Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell-Targeted Therapy in the Trial of Anti-B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS).
Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray-Brown WJ, Lucchesi D, Fossati-Jimack L, Nerviani A, Jaworska E, Ghirardi GM, Giacomassi C, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Seror R, Mariette X, Porcher R, Cavallaro G, Pulvirenti A, Verstappen GM, de Wolff L, Arends S, Bootsma H, Lewis MJ, Pitzalis C, Bowman SJ, Bombardieri M; Trial for Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome Study Research Group. Pontarini E, et al. Among authors: sciacca e. Arthritis Rheumatol. 2024 May;76(5):763-776. doi: 10.1002/art.42772. Epub 2024 Feb 15. Arthritis Rheumatol. 2024. PMID: 38073013 Clinical Trial.
Highlights on Future Treatments of IPF: Clues and Pitfalls.
Libra A, Sciacca E, Muscato G, Sambataro G, Spicuzza L, Vancheri C. Libra A, et al. Among authors: sciacca e. Int J Mol Sci. 2024 Aug 1;25(15):8392. doi: 10.3390/ijms25158392. Int J Mol Sci. 2024. PMID: 39125962 Free PMC article. Review.
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.
Lewis MJ, Çubuk C, Surace AEA, Sciacca E, Lau R, Goldmann K, Giorli G, Fossati-Jimack L, Nerviani A, Rivellese F, Pitzalis C; STRAP collaborative group. Lewis MJ, et al. Among authors: sciacca e. Nat Commun. 2025 Jul 2;16(1):5374. doi: 10.1038/s41467-025-60987-9. Nat Commun. 2025. PMID: 40603860 Free PMC article. Clinical Trial.
Transcriptomic profiling of Sjögren's disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity.
Pontarini E, Lucchesi D, Sciacca E, Cavallaro G, Song Q, Galbraith D, Thomas E, Marino A, Sutcliffe N, Tappuni AR, Giacomelli R, Pulvirenti A, Bowman SJ, Hao LY, Sivils K, Pitzalis C, Lewis MJ, Bombardieri M. Pontarini E, et al. Among authors: sciacca e. Ann Rheum Dis. 2025 Nov;84(11):1822-1835. doi: 10.1016/j.ard.2025.07.021. Epub 2025 Aug 21. Ann Rheum Dis. 2025. PMID: 40846589 Free article.
24 results