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Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
Torrico F, Gascon J, Ortiz L, Alonso-Vega C, Pinazo MJ, Schijman A, Almeida IC, Alves F, Strub-Wourgaft N, Ribeiro I; E1224 Study Group. Torrico F, et al. Lancet Infect Dis. 2018 Apr;18(4):419-430. doi: 10.1016/S1473-3099(17)30538-8. Epub 2018 Jan 16. Lancet Infect Dis. 2018. PMID: 29352704 Free PMC article. Clinical Trial.
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials.
Watson JA, Cruz C, Barreira F, Forsyth C, Schijman AG, Peploe R, Assmus F, Naylor C, Lee J, Mehra S, Tarning J, Torrico F, Gascon J, Ortiz L, Ribeiro I, Sosa-Estani S, Tipple C, Hugonnet S, Guérin PJ, Fraisse L, Pinazo MJ, White NJ; E1224; BENDITA Study Groups. Watson JA, et al. Lancet Microbe. 2025 Oct;6(10):101156. doi: 10.1016/j.lanmic.2025.101156. Epub 2025 Sep 9. Lancet Microbe. 2025. PMID: 40934940 Free article. Clinical Trial.