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12,305 results

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Page 1
Showing results for serine ae
Search for Serize AE instead (2 results)
Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Ghrayeb A, et al. Cell Metab. 2024 Jan 2;36(1):116-129.e7. doi: 10.1016/j.cmet.2023.12.013. Cell Metab. 2024. PMID: 38171331 Free PMC article.
Stable-isotope tracing demonstrated that increased serine synthesis from glycine via reverse serine hydroxymethyltransferase (SHMT) is the underlying cause for decreased glycine in steatotic livers. ...
Stable-isotope tracing demonstrated that increased serine synthesis from glycine via reverse serine hydroxymethyltransferase ( …
Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells.
Gu HC, Wang LF, Zhang YW, Zhuo YQ, Zhang ZH, Wei XY, Liu QW, Deng KY, Xin HB. Gu HC, et al. Cell Mol Biol Lett. 2025 Feb 19;30(1):21. doi: 10.1186/s11658-025-00701-1. Cell Mol Biol Lett. 2025. PMID: 39972244 Free PMC article.
In addition, we observed that miR-27b-3p was highly expressed in hUSC-Exo and markedly suppressed CTX-induced GC apoptosis by specifically inhibiting the expression of SLC1A4, a serine transporter, in ovarian GCs, which, in turn, elevated the concentration of the intracell …
In addition, we observed that miR-27b-3p was highly expressed in hUSC-Exo and markedly suppressed CTX-induced GC apoptosis by specifically i …
Efficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.
Cole J, Sohn MN, Harris AD, Bray SL, Patten SB, McGirr A. Cole J, et al. JAMA Psychiatry. 2022 Dec 1;79(12):1153-1161. doi: 10.1001/jamapsychiatry.2022.3255. JAMA Psychiatry. 2022. PMID: 36223114 Free PMC article. Clinical Trial.
IMPORTANCE: The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought to depend on synaptic plasticity. ...This was reflected in lower CGI-severity ratings and greater CGI-improvement ratings. No serious ad …
IMPORTANCE: The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought …
Efficacy and safety of ceftazidime/avibactam in patients with infections caused by β-lactamase-producing Gram-negative pathogens: a pooled analysis from the Phase 3 clinical trial programme.
Torres A, Wible M, Tawadrous M, Irani P, Stone GG, Quintana A, Debabov D, Burroughs M, Bradford PA, Kollef M. Torres A, et al. J Antimicrob Chemother. 2023 Nov 6;78(11):2672-2682. doi: 10.1093/jac/dkad280. J Antimicrob Chemother. 2023. PMID: 37700689 Free PMC article. Clinical Trial.
Clinical and microbiological responses at the test-of-cure visit were assessed for patients with ESBLs, and/or plasmidic and/or overexpression of chromosomal AmpC, and/or serine carbapenemases without MBLs identified in baseline Gram-negative isolates by phenotypic screeni …
Clinical and microbiological responses at the test-of-cure visit were assessed for patients with ESBLs, and/or plasmidic and/or overexpressi …
AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis.
Zhang X, Zeng Y, Ying H, Hong Y, Xu J, Lin R, Chen Y, Wu X, Cai W, Xia Z, Zhao Q, Wang Y, Zhou R, Zhu D, Yu F. Zhang X, et al. Ecotoxicol Environ Saf. 2025 Jan 1;289:117511. doi: 10.1016/j.ecoenv.2024.117511. Epub 2024 Dec 10. Ecotoxicol Environ Saf. 2025. PMID: 39662457 Free article.
Our findings demonstrated that AdipoRon effectively suppressed ATF4-mediated endoplasmic reticulum stress in HSCs and assumed a crucial role in hindering serine/glycine biosynthesis. Interestingly, this inhibitory effect of AdipoRon on serine/glycine biosynthesis is …
Our findings demonstrated that AdipoRon effectively suppressed ATF4-mediated endoplasmic reticulum stress in HSCs and assumed a crucial role …
Pharmacokinetics and toxicokinetics of d-serine in rats.
Hasegawa H, Masuda N, Natori H, Shinohara Y, Ichida K. Hasegawa H, et al. J Pharm Biomed Anal. 2019 Jan 5;162:264-271. doi: 10.1016/j.jpba.2018.09.026. Epub 2018 Sep 14. J Pharm Biomed Anal. 2019. PMID: 30268994
The oral bioavailability of d-serine was estimated to be 94 27%. To evaluate the dose-response relationship of d-serine-induced kidney injury and the plasma kinetics of d-serine, we injected d-serine into rats ip in doses ranging from 0.6 to 4.8 mmol/k …
The oral bioavailability of d-serine was estimated to be 94 27%. To evaluate the dose-response relationship of d-serine-induce …
Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARgamma serine 273 phosphorylation.
Haas B, Hass MDS, Voltz A, Vogel M, Walther J, Biswas A, Hass D, Pfeifer A. Haas B, et al. Mol Metab. 2024 Jul;85:101956. doi: 10.1016/j.molmet.2024.101956. Epub 2024 May 10. Mol Metab. 2024. PMID: 38735390 Free PMC article.
In HFD mice SUs reduce PPARgamma phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs increase UCP1 expression and reduce lipid droplets sizes. CONCLUSIONS: Our findings indicate that a part of SUs extra-pancreatic effects …
In HFD mice SUs reduce PPARgamma phosphorylation in WAT and have comparable effects on gene expression to rosiglitazone. In BAT SUs i …
L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis.
López-Gonzales E, Lehmann L, Ruiz-Ojeda FJ, Hernández-Bautista R, Altun I, Onogi Y, Khalil AE, Liu X, Israel A, Ussar S. López-Gonzales E, et al. Nutrients. 2022 May 4;14(9):1922. doi: 10.3390/nu14091922. Nutrients. 2022. PMID: 35565889 Free PMC article.
Thus, novel interventions maintaining reduced body weight are critically important to prevent metabolic disease. Here we investigate the metabolic effects of dietary L-serine supplementation, known to modulate various organ functions. ...Conversely, L-serine …
Thus, novel interventions maintaining reduced body weight are critically important to prevent metabolic disease. Here we investigate the met …
12,305 results
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