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Page 1
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer.
Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Moro-Sibilot D, Goldwasser F, Silva CAC, Terrisse S, Bonvalet M, Scherpereel A, Pegliasco H, Richard C, Ghiringhelli F, Elkrief A, Desilets A, Blanc-Durand F, Cumbo F, Blanco A, Boidot R, Chevrier S, Daillère R, Kroemer G, Alla L, Pons N, Le Chatelier E, Galleron N, Roume H, Dubuisson A, Bouchard N, Messaoudene M, Drubay D, Deutsch E, Barlesi F, Planchard D, Segata N, Martinez S, Zitvogel L, Soria JC, Besse B. Derosa L, et al. Among authors: silva cac. Nat Med. 2022 Feb;28(2):315-324. doi: 10.1038/s41591-021-01655-5. Epub 2022 Feb 3. Nat Med. 2022. PMID: 35115705 Free PMC article.
Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome.
Derosa L, Iebba V, Silva CAC, Piccinno G, Wu G, Lordello L, Routy B, Zhao N, Thelemaque C, Birebent R, Marmorino F, Fidelle M, Messaoudene M, Thomas AM, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Sibilot DM, Goldwasser F, Scherpereel A, Pegliasco H, Ghiringhelli F, Bouchard N, Sow C, Darik I, Zoppi S, Ly P, Reni A, Daillère R, Deutsch E, Lee KA, Bolte LA, Björk JR, Weersma RK, Barlesi F, Padilha L, Finzel A, Isaksen ML, Escudier B, Albiges L, Planchard D, André F, Cremolini C, Martinez S, Besse B, Zhao L, Segata N, Wojcik J, Kroemer G, Zitvogel L. Derosa L, et al. Among authors: silva cac. Cell. 2024 Jun 20;187(13):3373-3389.e16. doi: 10.1016/j.cell.2024.05.029. Cell. 2024. PMID: 38906102 Free article.
Gut Microbiota-Related Biomarkers in Immuno-Oncology.
Silva CAC, Fidelle M, Almonte AA, Derosa L, Zitvogel L. Silva CAC, et al. Annu Rev Pharmacol Toxicol. 2025 Jan;65(1):333-354. doi: 10.1146/annurev-pharmtox-061124-102218. Epub 2024 Dec 17. Annu Rev Pharmacol Toxicol. 2025. PMID: 39259979 Free article. Review.
Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS).
Barroso-Sousa R, Zanudo JGT, Li T, Reddy SM, Emens LA, Kuntz TM, Silva CAC, AlDubayan SH, Chu H, Overmoyer B, Lange P, DiLullo MK, Montesion M, Kasparian J, Hughes ME, Attaya V, Basta A, Lin NU, Tayob N, Jeselsohn R, Mittendorf EA, Tolaney SM. Barroso-Sousa R, et al. Among authors: silva cac. Nat Commun. 2025 May 13;16(1):4430. doi: 10.1038/s41467-025-59695-1. Nat Commun. 2025. PMID: 40360544 Free PMC article. Clinical Trial.
A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research.
Metwaly A, Kriaa A, Hassani Z, Carraturo F, Druart C; IHMCSA Consortium; Arnauts K, Wilmes P, Walter J, Rosshart S, Desai MS, Dore J, Fasano A, Blottiere HM, Maguin E, Haller D. Metwaly A, et al. Nat Rev Gastroenterol Hepatol. 2025 May;22(5):343-356. doi: 10.1038/s41575-025-01041-3. Epub 2025 Mar 3. Nat Rev Gastroenterol Hepatol. 2025. PMID: 40033063 Review.
Optimizing muscle mass and function in advanced lung cancer patients: randomized, double-blind, placebo-controlled trial protocol using High Eicosapentaenoic acid and PROtein (HEPRO) to modulate epigenetics, reduce toxicity and improve gut microbiota.
Borchardt I, Prado C, Montella T, Moreira GF, Farias G, Reis MX, Taveira F, Dias FC, De Marchi P, Davalos A, Silva CAC, Ferreira CG, Melo A, Peres W. Borchardt I, et al. Among authors: silva cac. PeerJ. 2025 Jun 3;13:e19506. doi: 10.7717/peerj.19506. eCollection 2025. PeerJ. 2025. PMID: 40487055 Free PMC article.
Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients.
Bourgin M, Derosa L, Silva CAC, Goubet AG, Dubuisson A, Danlos FX, Grajeda-Iglesias C, Cerbone L, Geraud A, Laparra A, Aprahamian F, Nirmalathasan N, Madeo F, Zitvogel L, Kroemer G, Durand S. Bourgin M, et al. Among authors: silva cac. Aging (Albany NY). 2021 Sep 13;13(17):20860-20885. doi: 10.18632/aging.203525. Epub 2021 Sep 13. Aging (Albany NY). 2021. PMID: 34517343 Free PMC article.
Impact of the ONCOBIOME network in cancer microbiome research.
Zitvogel L, Derosa L, Routy B, Loibl S, Heinzerling L, de Vries IJM, Engstrand L; ONCOBIOME Network; Segata N, Kroemer G. Zitvogel L, et al. Nat Med. 2025 Apr;31(4):1085-1098. doi: 10.1038/s41591-025-03608-8. Epub 2025 Apr 11. Nat Med. 2025. PMID: 40217075 Review.
Microbiome testing in Europe: navigating analytical, ethical and regulatory challenges.
Rodriguez J, Cordaillat-Simmons M, Badalato N, Berger B, Breton H, de Lahondès R, Deschasaux-Tanguy M, Desvignes C, D'Humières C, Kampshoff S, Lavelle A, Metwaly A, Quijada NM, Seegers JFML, Udocor A, Zwart H; Human Microbiome Action Consortium; Maguin E, Doré J, Druart C. Rodriguez J, et al. Microbiome. 2024 Dec 18;12(1):258. doi: 10.1186/s40168-024-01991-x. Microbiome. 2024. PMID: 39695869 Free PMC article.
The interplay between gut microbiota, antibiotics, and immune checkpoint inhibitors in patients with cancer: A narrative review with biological and clinical aspects.
Wekking D, Silva CAC, Viscò R, Denaro N, Lambertini M, Maccioni A, Loddo E, Willard-Gallo K, Scartozzi M, Derosa L, Solinas C. Wekking D, et al. Among authors: silva cac. Crit Rev Oncol Hematol. 2025 Aug;212:104767. doi: 10.1016/j.critrevonc.2025.104767. Epub 2025 May 23. Crit Rev Oncol Hematol. 2025. PMID: 40414545 Free article. Review.
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