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58 results

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Page 1
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Chen B, et al. Among authors: simmons aj. Cell. 2021 Dec 22;184(26):6262-6280.e26. doi: 10.1016/j.cell.2021.11.031. Epub 2021 Dec 14. Cell. 2021. PMID: 34910928 Free PMC article.
Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.
Heiser CN, Simmons AJ, Revetta F, McKinley ET, Ramirez-Solano MA, Wang J, Kaur H, Shao J, Ayers GD, Wang Y, Glass SE, Tasneem N, Chen Z, Qin Y, Kim W, Rolong A, Chen B, Vega PN, Drewes JL, Markham NO, Saleh N, Nikolos F, Vandekar S, Jones AL, Washington MK, Roland JT, Chan KS, Schürpf T, Sears CL, Liu Q, Shrubsole MJ, Coffey RJ, Lau KS. Heiser CN, et al. Among authors: simmons aj. Cell. 2023 Dec 7;186(25):5620-5637.e16. doi: 10.1016/j.cell.2023.11.006. Cell. 2023. PMID: 38065082 Free PMC article.
Temporal recording of mammalian development and precancer.
Islam M, Yang Y, Simmons AJ, Shah VM, Musale KP, Xu Y, Tasneem N, Chen Z, Trinh LT, Molina P, Ramirez-Solano MA, Sadien ID, Dou J, Rolong A, Chen K, Magnuson MA, Rathmell JC, Macara IG, Winton DJ, Liu Q, Zafar H, Kalhor R, Church GM, Shrubsole MJ, Coffey RJ, Lau KS. Islam M, et al. Among authors: simmons aj. Nature. 2024 Oct;634(8036):1187-1195. doi: 10.1038/s41586-024-07954-4. Epub 2024 Oct 30. Nature. 2024. PMID: 39478207 Free PMC article.
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.
Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH; Human Tumor Atlas Network. Rozenblatt-Rosen O, et al. Cell. 2020 Apr 16;181(2):236-249. doi: 10.1016/j.cell.2020.03.053. Cell. 2020. PMID: 32302568 Free PMC article. Review.
Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation.
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS. Banerjee A, et al. Among authors: simmons aj. Gastroenterology. 2020 Dec;159(6):2101-2115.e5. doi: 10.1053/j.gastro.2020.08.029. Epub 2020 Aug 21. Gastroenterology. 2020. PMID: 32828819 Free PMC article.
Biofunctionalized gelatin hydrogels support development and maturation of iPSC-derived cortical organoids.
Kjar A, Haschert MR, Zepeda JC, Simmons AJ, Yates A, Chavarria D, Fernandez M, Robertson G, Abdulrahman AM, Kim H, Marguerite NT, Moen RK, Drake LE, Curry CW, O'Grady BJ, Gama V, Lau KS, Grueter B, Brunger JM, Lippmann ES. Kjar A, et al. Among authors: simmons aj. Cell Rep. 2024 Nov 26;43(11):114874. doi: 10.1016/j.celrep.2024.114874. Epub 2024 Oct 17. Cell Rep. 2024. PMID: 39423129 Free PMC article.
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.
Li J, Simmons AJ, Hawkins CV, Chiron S, Ramirez-Solano MA, Tasneem N, Kaur H, Xu Y, Revetta F, Vega PN, Bao S, Cui C, Tyree RN, Raber LW, Conner AN, Pilat JM, Jacobse J, McNamara KM, Allaman MM, Raffa GA, Gobert AP, Asim M, Goettel JA, Choksi YA, Beaulieu DB, Dalal RL, Horst SN, Pabla BS, Huo Y, Landman BA, Roland JT, Scoville EA, Schwartz DA, Washington MK, Shyr Y, Wilson KT, Coburn LA, Lau KS, Liu Q. Li J, et al. Among authors: simmons aj. Nat Commun. 2024 Aug 22;15(1):7204. doi: 10.1038/s41467-024-51580-7. Nat Commun. 2024. PMID: 39169060 Free PMC article.
Interleukin 13 Promotes Maturation and Proliferation in Metaplastic Gastroids.
Contreras-Panta EW, Lee SH, Won Y, Norlander AE, Simmons AJ, Peebles RS Jr, Lau KS, Choi E, Goldenring JR. Contreras-Panta EW, et al. Among authors: simmons aj. Cell Mol Gastroenterol Hepatol. 2024;18(3):101366. doi: 10.1016/j.jcmgh.2024.101366. Epub 2024 May 29. Cell Mol Gastroenterol Hepatol. 2024. PMID: 38815928 Free PMC article.
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer.
Glass SE, Bechard ME, Cao Z, Aramandla R, Zhao P, Ellis ST, Green EH, Fisher EG, Smith RT, Sievers CK, Irudayam MJ, Revetta F, Washington MK, Ayers GD, Heiser CN, Simmons AJ, Xu Y, Wang Y, Windon A, Shrubsole MJ, Markham NO, Liu Q, Lau KS, Coffey RJ. Glass SE, et al. Among authors: simmons aj. JCI Insight. 2025 Apr 3;10(9):e186938. doi: 10.1172/jci.insight.186938. eCollection 2025 May 8. JCI Insight. 2025. PMID: 40178918 Free PMC article.
MTGR1 is required to maintain small intestinal stem cell populations.
Short SP, Brown RE, Chen Z, Pilat JM, McElligott BA, Meenderink LM, Bickart AC, Blunt KM, Jacobse J, Wang J, Simmons AJ, Xu Y, Yang Y, Parang B, Choksi YA, Goettel JA, Lau KS, Hiebert SW, Williams CS. Short SP, et al. Among authors: simmons aj. Cell Death Differ. 2024 Sep;31(9):1170-1183. doi: 10.1038/s41418-024-01346-x. Epub 2024 Jul 25. Cell Death Differ. 2024. PMID: 39048708 Free PMC article.
58 results