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1,855 results

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Page 1
Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene.
Vachtenheim J Jr, Lischke R, Vachtenheim J. Vachtenheim J Jr, et al. Onco Targets Ther. 2018 Oct 1;11:6361-6367. doi: 10.2147/OTT.S173001. eCollection 2018. Onco Targets Ther. 2018. PMID: 30319276 Free PMC article. Review.
Siva-1 is a typical apoptotic protein commonly activated by the p53 tumor suppressor protein and should therefore participate in a barrier against the development of cancer. ...Herein, we review reported activities of Siva-1 in various experimental settings and comm …
Siva-1 is a typical apoptotic protein commonly activated by the p53 tumor suppressor protein and should therefore participate in a ba …
FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function.
Coccia E, Solé M, Comella JX. Coccia E, et al. Front Cell Dev Biol. 2022 Jan 10;9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021. Front Cell Dev Biol. 2022. PMID: 35083225 Free PMC article. Review.
Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA- …
Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling pres …
Siva plays a critical role in mouse embryonic development.
Jacobs SBR, Van Nostrand JL, Bowen ME, Baker JC, Attardi LD. Jacobs SBR, et al. Cell Death Differ. 2020 Jan;27(1):297-309. doi: 10.1038/s41418-019-0358-x. Epub 2019 Jun 4. Cell Death Differ. 2020. PMID: 31164717 Free PMC article.
Here, we generate Siva knockout mice to characterize the physiological function of Siva in vivo. Interestingly, we find that Siva deficiency causes early embryonic lethality accompanied by multiple phenotypes, including developmental delay, abnormal neural tu …
Here, we generate Siva knockout mice to characterize the physiological function of Siva in vivo. Interestingly, we find that …
Multifaceted functions of Siva-1: more than an Indian God of Destruction.
Mei Y, Wu M. Mei Y, et al. Protein Cell. 2012 Feb;3(2):117-22. doi: 10.1007/s13238-012-2018-5. Epub 2012 Mar 17. Protein Cell. 2012. PMID: 22426980 Free PMC article. Review.
Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppres …
Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-media …
Siva 1 Inhibits Cervical Cancer Progression and Its Clinical Prognosis Significance.
Liu T, Ma Y, Wang Z, Zhang W, Yang X. Liu T, et al. Cancer Manag Res. 2020 Jan 15;12:303-311. doi: 10.2147/CMAR.S232994. eCollection 2020. Cancer Manag Res. 2020. PMID: 32021444 Free PMC article.
We up-regulated the expression of Siva 1 by plasmid pCMV3-Siva 1 in C33A cells. CCK8, flow cytometry, wound-healing, and transwell assays were performed to examine the influences of Siva 1 expression on cell proliferation, apoptosis, migration and invasion. . …
We up-regulated the expression of Siva 1 by plasmid pCMV3-Siva 1 in C33A cells. CCK8, flow cytometry, wound-healing, and trans …
World SIVA: the pediatric initiative.
Mason KP. Mason KP. Paediatr Anaesth. 2010 Mar;20(3):209-10. doi: 10.1111/j.1460-9592.2009.03243.x. Paediatr Anaesth. 2010. PMID: 20470318
Siva-1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF-kappaB pathway.
Kong FB, Deng QM, Deng HQ, Dong CC, Li L, He CG, Wang XT, Xu S, Mai W. Kong FB, et al. Mol Med Rep. 2020 Aug;22(2):1558-1566. doi: 10.3892/mmr.2020.11211. Epub 2020 Jun 3. Mol Med Rep. 2020. PMID: 32626967 Free PMC article.
Siva-1 is a well-known anti-apoptosis protein that serves a role in multiple types of cancer cells. ...The present study aimed to determine the possible involvement of Siva-1 in gastric cancer anticancer drug resistance in vitro. A vincristine (VCR)-resistant KATO I …
Siva-1 is a well-known anti-apoptosis protein that serves a role in multiple types of cancer cells. ...The present study aimed to det …
SIVA-1 enhances acquired chemotherapeutic drug resistance of gastric cancer in vivo by regulating the ARF/MDM2/p53 pathway.
Wang XT, Li L, Zhu Z, Huang YL, Chen HH, Shi ZY, Deng QM, Wu K, Xia LJ, Mai W, Yang JR, Kong FB. Wang XT, et al. Heliyon. 2024 Jan 11;10(2):e24394. doi: 10.1016/j.heliyon.2024.e24394. eCollection 2024 Jan 30. Heliyon. 2024. PMID: 38312638 Free PMC article.
SIVA-1 has been shown to affect apoptotic processes in various different cell lines, and SIVA-1 significantly contributes to the decreased responsiveness of cancer cells to some chemotherapy agents. ...Immunohistochemical assays of xenograft tumor showed that SIV …
SIVA-1 has been shown to affect apoptotic processes in various different cell lines, and SIVA-1 significantly contributes to t …
Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1.
Kong F, Wu K, Pang L, Huang Y, Li L, Xu J, Li F, Qing Y, Wang Z, Huang X, Xu S, Zhong X, Zhu Z, Wang X, Yang J. Kong F, et al. Oncol Res. 2023 Feb 9;30(6):277-288. doi: 10.32604/or.2022.027301. eCollection 2022. Oncol Res. 2023. PMID: 37303491 Free PMC article.
RESULTS: Siva-1 downregulation reduced the pump rate of doxorubicin and enhanced the response to drug treatment. Siva-1 negatively regulated proliferation and promoted apoptosis of cells by potentiality G2-M phase arresting. ...
RESULTS: Siva-1 downregulation reduced the pump rate of doxorubicin and enhanced the response to drug treatment. Siva-1 negati …
Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.
Xue L, Chu F, Cheng Y, Sun X, Borthakur A, Ramarao M, Pandey P, Wu M, Schlossman SF, Prasad KV. Xue L, et al. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6925-30. doi: 10.1073/pnas.102182299. Proc Natl Acad Sci U S A. 2002. PMID: 12011449 Free PMC article.
The Siva gene is organized into four exons that code for the predominant full-length Siva-1 transcript, whereas its alternate splice form, Siva-2, lacks exon 2 coding sequence. Various groups have demonstrated a role for Siva-1 in several apoptotic pat …
The Siva gene is organized into four exons that code for the predominant full-length Siva-1 transcript, whereas its alternate …
1,855 results