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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1799 1
1800 2
1801 5
1802 1
1806 9
1807 10
1808 3
1815 1
1824 1
1867 2
1878 1
1887 1
1888 1
1891 1
1908 1
1909 2
1910 3
1911 2
1912 2
1913 5
1914 2
1916 3
1917 3
1919 1
1920 4
1921 2
1922 2
1923 2
1925 1
1927 2
1928 2
1930 3
1931 1
1932 1
1933 2
1934 2
1935 2
1936 1
1941 1
1943 1
1944 1
1945 2
1946 4
1947 1
1948 5
1949 5
1950 2
1951 2
1952 2
1953 9
1954 8
1955 10
1956 7
1957 4
1958 12
1959 9
1960 11
1961 23
1962 22
1963 36
1964 53
1965 55
1966 85
1967 116
1968 130
1969 197
1970 212
1971 239
1972 425
1973 490
1974 536
1975 907
1976 870
1977 880
1978 853
1979 903
1980 1036
1981 1108
1982 1248
1983 1408
1984 1610
1985 1763
1986 1593
1987 1729
1988 2021
1989 2177
1990 2256
1991 2664
1992 3093
1993 3497
1994 3619
1995 3969
1996 4209
1997 4394
1998 4592
1999 4804
2000 4943
2001 5053
2002 4899
2003 5214
2004 5639
2005 5826
2006 6057
2007 6220
2008 6201
2009 6323
2010 6654
2011 6922
2012 7344
2013 7616
2014 7958
2015 8036
2016 8321
2017 8193
2018 8012
2019 8434
2020 9120
2021 9515
2022 8671
2023 8238
2024 8181
2025 8408
2026 2162

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230,006 results

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Page 1
End resection at double-strand breaks: mechanism and regulation.
Symington LS. Symington LS. Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8):a016436. doi: 10.1101/cshperspect.a016436. Cold Spring Harb Perspect Biol. 2014. PMID: 25085909 Free PMC article. Review.
RecA/Rad51 catalyzed pairing of homologous DNA strands, initiated by polymerization of the recombinase on single-stranded DNA (ssDNA), is a universal feature of homologous recombination (HR). Generation of ssDNA from a double-strand break (DSB) requires nucle …
RecA/Rad51 catalyzed pairing of homologous DNA strands, initiated by polymerization of the recombinase on single-stranded DNA …
Strand asymmetries in DNA evolution.
Francino MP, Ochman H. Francino MP, et al. Trends Genet. 1997 Jun;13(6):240-5. doi: 10.1016/S0168-9525(97)01118-9. Trends Genet. 1997. PMID: 9196330 Free article. Review.
The complementary strands of DNA differ with respect to replication and transcription. Both of these processes are asymmetric and can bias the occurrence of mutations between the strands: during replication, the discontinuous lagging strand undergoes certain …
The complementary strands of DNA differ with respect to replication and transcription. Both of these processes are asymmetric and can …
Strand-preferred base editing of organellar and nuclear genomes using CyDENT.
Hu J, Sun Y, Li B, Liu Z, Wang Z, Gao Q, Guo M, Liu G, Zhao KT, Gao C. Hu J, et al. Nat Biotechnol. 2024 Jun;42(6):936-945. doi: 10.1038/s41587-023-01910-9. Epub 2023 Aug 28. Nat Biotechnol. 2024. PMID: 37640945
Transcription-activator-like effector (TALE)-based tools for base editing of nuclear and organellar DNA rely on double-stranded DNA deaminases, which edit substrate bases on both strands of DNA, reducing editing precision. Here, we present CyDENT base editing, a CRI …
Transcription-activator-like effector (TALE)-based tools for base editing of nuclear and organellar DNA rely on double-stranded DNA d …
Strand-specific fluorescence in situ hybridization: the CO-FISH family.
Bailey SM, Goodwin EH, Cornforth MN. Bailey SM, et al. Cytogenet Genome Res. 2004;107(1-2):14-7. doi: 10.1159/000079565. Cytogenet Genome Res. 2004. PMID: 15305050 Review.
This usually involves denaturation of double-stranded probes to induce temporary separation of the DNA strands. Strand-specific FISH (CO-FISH; Chromosome Orientation-FISH) involves selective removal of newly replicated strands from DNA of metaphase chr …
This usually involves denaturation of double-stranded probes to induce temporary separation of the DNA strands. Strand- …
A proposal: Source of single strand DNA that elicits the SOS response.
Indiani C, O'Donnell M. Indiani C, et al. Front Biosci (Landmark Ed). 2013 Jan 1;18(1):312-23. doi: 10.2741/4102. Front Biosci (Landmark Ed). 2013. PMID: 23276924 Free PMC article. Review.
Recent studies indicate another source of the single-strand DNA, resulting from an inherently dynamic replisome that may hop over template lesions on both leading and lagging strands, thereby leaving single-strand gaps in the wake of the replication fork. The …
Recent studies indicate another source of the single-strand DNA, resulting from an inherently dynamic replisome that may hop over tem …
3' Nucleotide Asymmetry Directs miRNA Strand Selection.
Medley JC, Moriya SK, Ouyang H, Crawshaw H, Zhang SY, Panzade G, Sydzyik WJ, Sydzyik JT, Bhandari M, Hammell CM, Zinovyeva A. Medley JC, et al. bioRxiv [Preprint]. 2025 Oct 16:2025.10.15.682714. doi: 10.1101/2025.10.15.682714. bioRxiv. 2025. PMID: 41278876 Free PMC article. Preprint.
During miRNA biogenesis, double-stranded precursors are processed into duplexes comprising functionally distinct strands. ...We propose that terminal nucleotide asymmetries on both strands of miRNA duplexes promote accurate strand selection in vivo....
During miRNA biogenesis, double-stranded precursors are processed into duplexes comprising functionally distinct strands. ...W …
Non-complementary strand commutation as a fundamental alternative for information processing by DNA and gene regulation.
Nikitin MP. Nikitin MP. Nat Chem. 2023 Jan;15(1):70-82. doi: 10.1038/s41557-022-01111-y. Epub 2023 Jan 5. Nat Chem. 2023. PMID: 36604607
The discovery of the DNA double helix has revolutionized our understanding of data processing in living systems, with the complementarity of the two DNA strands providing a reliable mechanism for the storage of hereditary information. Here I reveal the 'strand commu …
The discovery of the DNA double helix has revolutionized our understanding of data processing in living systems, with the complementarity of …
Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.
Yu C, Gan H, Zhang Z. Yu C, et al. Methods Mol Biol. 2018;1672:227-238. doi: 10.1007/978-1-4939-7306-4_17. Methods Mol Biol. 2018. PMID: 29043628
DNA replication initiates at DNA replication origins after unwinding of double-strand DNA(dsDNA) by replicative helicase to generate single-stranded DNA (ssDNA) templates for the continuous synthesis of leading-strand and the discontinuous synthesis of laggin …
DNA replication initiates at DNA replication origins after unwinding of double-strand DNA(dsDNA) by replicative helicase to generate …
RAD51 D-loop structures reveal the mechanism of eukaryotic RAD51-mediated strand exchange.
Luo SC, Yang CH, Yeh HY, Lin CW, Yeh MC, Chi P, Ho MC. Luo SC, et al. Nat Commun. 2025 Dec 1;17(1):243. doi: 10.1038/s41467-025-66925-z. Nat Commun. 2025. PMID: 41326376 Free PMC article.
Strand exchange is a key step in homologous recombination, enabling template-based repair of DNA double-strand breaks. Eukaryotic RAD51 forms an ATP-dependent helical presynaptic filament on single-stranded DNA (ssDNA), which then searches for homologous doub …
Strand exchange is a key step in homologous recombination, enabling template-based repair of DNA double-strand breaks. Eukaryo …
Rolling-circle and strand-displacement mechanisms for non-enzymatic RNA replication at the time of the origin of life.
Tupper AS, Higgs PG. Tupper AS, et al. J Theor Biol. 2021 Oct 21;527:110822. doi: 10.1016/j.jtbi.2021.110822. Epub 2021 Jun 29. J Theor Biol. 2021. PMID: 34214567 Free article.
With some form of environmental cycling, such as temperature, salinity, or pH cycling, double-stranded RNA can be melted to form single-stranded RNA, although re-annealing of existing strands would then occur much faster than synthesis of new strands. …
With some form of environmental cycling, such as temperature, salinity, or pH cycling, double-stranded RNA can be melted to form sing …
230,006 results
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