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Page 1
Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Brierley CK, Yip BH, Orlando G, Wen J, Wen S, Goyal H, Levine M, Jakobsdottir GM, Tapinos A, Cornish AJ, Rodriguez-Romera A, Rodriguez-Meira A, Bashton M, Hamblin A, Clark SA, Hamley JC, Fox O, Giurgiu M, O'Sullivan J, Murphy L, Adamo A, Olijnik AA, Cotton A, Hendrix E, Narina S, Pruett-Miller SM, Enshaei A, Harrison C, Drummond M, Knapper S, Tefferi A, Antony-Debré I, Davies J, Henssen AG, Thongjuea S, Wedge DC, Constantinescu SN, Papaemmanuil E, Psaila B, Crispino JD, Mead AJ. Brierley CK, et al. Among authors: tapinos a. Nat Genet. 2025 Jun;57(6):1478-1492. doi: 10.1038/s41588-025-02190-6. Epub 2025 Jun 9. Nat Genet. 2025. PMID: 40490510 Free PMC article.
Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project.
Ní Leathlobhair M, Frangou A, Kinnersley B, Cornish AJ, Chubb D, Lakatos E, Arumugam P, Gruber AJ, Law P, Tapinos A, Jakobsdottir GM, Peneva I, Sahli A, Smyth EM, Ball RY, Sylva R, Benes K, Stark D, Young RJ, Lee ATJ, Wolverson V, Houlston RS, Sosinsky A, Protheroe A, Murray MJ, Wedge DC, Verrill C; Testicular Cancer Genomics England Clinical Interpretation Partnership Consortium; Genomics England Research Consortium. Ní Leathlobhair M, et al. Among authors: tapinos a. Nat Commun. 2024 Oct 26;15(1):9247. doi: 10.1038/s41467-024-53193-6. Nat Commun. 2024. PMID: 39461959 Free PMC article.
Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry.
Gheybi K, Soh PXY, Jiang J, Mbeki TMN, Louw M, Burns D, Mundra P, Kiriy D, Hasan MM, Jaratlerdsiri W, Lebelo MT, Campbell RA, Radzuma MB, Nenzhelele M, Obida M, Obida M, Ombuki WM, Oyaro MO, Patrick SM, Loda M, Wedge DC, Bristow RG, Brewer DS, Cooper CS, Reimand J, Cancel-Tassin G, Cussenot O, Hovens CM, Cocoran NM, Stricker PD, Schlomm T, Prins GS, Sørensen KD; Pan Prostate Cancer Group; HEROIC PCaPH Africa1K; Weischenfeldt J, Mutambirwa SBA, Ngugi PM, Thomas DM, Kote-Jarai Z, Eeles RA, Bornman MSR, Hayes VM. Gheybi K, et al. Nat Commun. 2025 Oct 2;16(1):8799. doi: 10.1038/s41467-025-63865-6. Nat Commun. 2025. PMID: 41038821 Free PMC article.
Challenges in the analysis of viral metagenomes.
Rose R, Constantinides B, Tapinos A, Robertson DL, Prosperi M. Rose R, et al. Among authors: tapinos a. Virus Evol. 2016 Aug 3;2(2):vew022. doi: 10.1093/ve/vew022. eCollection 2016 Jul. Virus Evol. 2016. PMID: 29492275 Free PMC article. Review.
Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions.
Zhu B, Tapinos A, Koka H, Yi Lee PM, Zhang T, Zhu W, Wang X, Klein A, Lee D, Tse GM, Tsang KH, Wu C, Hua M, Highfill CA, Lenz P, Zhou W, Wang D, Luo W, Jones K, Hutchinson A, Hicks B, Garcia-Closas M, Chanock S, Tse LA, Wedge DC, Yang XR. Zhu B, et al. Among authors: tapinos a. Am J Hum Genet. 2024 Dec 5;111(12):2773-2788. doi: 10.1016/j.ajhg.2024.10.005. Epub 2024 Nov 3. Am J Hum Genet. 2024. PMID: 39492056 Free PMC article.
15 results