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957 results

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Page 1
The accuracy of the THIM wearable device for estimating sleep onset latency.
Scott H, Whitelaw A, Canty A, Lovato N, Lack L. Scott H, et al. J Clin Sleep Med. 2021 May 1;17(5):973-981. doi: 10.5664/jcsm.9070. J Clin Sleep Med. 2021. PMID: 33438575 Free PMC article.

There were moderate correlations between PSG and THIM on both nights [r((s)) > .57, P < .001]. In 23.74% of trials, PSG sleep onset could not be determined before THIM ended the trial. With a revised THIM algorithm in study 2, there was no significant d

…

There were moderate correlations between PSG and THIM on both nights [r((s)) > .57, P < .001]. In 23.74% of trials, PSG sleep o

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Alpha lipoic acid ameliorates THIM-induced prefrontal cell loss and abnormal enzymatically contents in the developing rat.
Noshadian M, Namvarpour Z, Amini A, Raoofi A, Atabati H, Sadeghi Y, Aliaghaei A, Abdollahifar MA. Noshadian M, et al. J Chem Neuroanat. 2020 Jan;103:101727. doi: 10.1016/j.jchemneu.2019.101727. Epub 2019 Nov 15. J Chem Neuroanat. 2020. PMID: 31740419
Today, it was somewhat clear that Thimerosal (THIM) is a neurotoxicant preservative. We aimed to use of a suitable agent for preventing of THIM side effects on brain. ...Male Wistar rats (n = 60) were randomly distributed into five groups: 1- THIM group; this …
Today, it was somewhat clear that Thimerosal (THIM) is a neurotoxicant preservative. We aimed to use of a suitable agent for preventi …
Regulation of the ThiM riboswitch is facilitated by the trapped structure formed during transcription of the wild-type sequence.
Du C, Wang Y, Gong S. Du C, et al. FEBS Lett. 2021 Nov;595(22):2816-2828. doi: 10.1002/1873-3468.14202. Epub 2021 Oct 30. FEBS Lett. 2021. PMID: 34644399 Free article.
The ThiM riboswitch from Escherichia coli is a typical mRNA device that modulates downstream gene expression by sensing TPP. ...Instead of stabilities of the genetic ON and OFF states, the transcription rate, pause, and ligand levels are combined to affect the ThiM …
The ThiM riboswitch from Escherichia coli is a typical mRNA device that modulates downstream gene expression by sensing TPP. ...Inste …
Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae.
Chen Y, Wang L, Shang F, Liu W, Lan J, Chen J, Ha NC, Quan C, Nam KH, Xu Y. Chen Y, et al. Biochem Biophys Res Commun. 2019 Oct 20;518(3):513-518. doi: 10.1016/j.bbrc.2019.08.086. Epub 2019 Aug 19. Biochem Biophys Res Commun. 2019. PMID: 31439375
In bacterial thiamin synthesis and salvage pathways, the 5-(hydroxyethyl)-methylthiazole kinase (ThiM) is essential in the pathway forming TPP. Thus, ThiM is considered to be an attractive antibacterial drug target. ...The structures will provide new insight into th …
In bacterial thiamin synthesis and salvage pathways, the 5-(hydroxyethyl)-methylthiazole kinase (ThiM) is essential in the pathway fo …
The Development and Accuracy of the THIM Wearable Device for Estimating Sleep and Wakefulness.
Scott H, Lovato N, Lack L. Scott H, et al. Nat Sci Sleep. 2021 Jan 12;13:39-53. doi: 10.2147/NSS.S287048. eCollection 2021. Nat Sci Sleep. 2021. PMID: 33469399 Free PMC article.
INTRODUCTION: THIM is a new wearable device worn on the finger that can passively monitor sleep and wakefulness overnight using actigraphy. ...Future research will examine the accuracy of THIM for monitoring sleep in people with insomnia....
INTRODUCTION: THIM is a new wearable device worn on the finger that can passively monitor sleep and wakefulness overnight using actig …
Conformational Dynamics of thiM Riboswitch To Understand the Gene Regulation Mechanism Using Markov State Modeling and the Residual Fluctuation Network Approach.
Kesherwani M, N H V K, Velmurugan D. Kesherwani M, et al. J Chem Inf Model. 2018 Aug 27;58(8):1638-1651. doi: 10.1021/acs.jcim.8b00155. Epub 2018 Jul 27. J Chem Inf Model. 2018. PMID: 29939019
To understand the dynamic behavior of TPP riboswitch upon TPP binding, molecular dynamics simulations were performed for 400 ns in both apo and TPP bound forms of thiM riboswitch from E. coli and analyzed in terms of eRMSD-based Markov state modeling and residual fluctuati …
To understand the dynamic behavior of TPP riboswitch upon TPP binding, molecular dynamics simulations were performed for 400 ns in both apo …
Purification, crystallization and preliminary X-ray diffraction analysis of ThiM from Staphylococcus aureus.
Drebes J, Perbandt M, Wrenger C, Betzel C. Drebes J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):479-81. doi: 10.1107/S1744309111004192. Epub 2011 Mar 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21505246 Free PMC article.
ThiM [5-(hydroxyethyl)-4-methylthiazole kinase; EC 2.7.1.50] from Staphylococcus aureus is an essential enzyme of thiamine or vitamin B(1) metabolism and has been crystallized by the vapour-diffusion method. ...
ThiM [5-(hydroxyethyl)-4-methylthiazole kinase; EC 2.7.1.50] from Staphylococcus aureus is an essential enzyme of thiamine or vitamin …
The thiM locus and its relation to phosphorylation of hydroxyethylthiazole in Escherichia coli.
Mizote T, Nakayama H. Mizote T, et al. J Bacteriol. 1989 Jun;171(6):3228-32. doi: 10.1128/jb.171.6.3228-3232.1989. J Bacteriol. 1989. PMID: 2542220 Free PMC article.
By conjugation and P1 transduction, a gene governing hydroxyethylthiazole kinase activity, for which we propose the designation thiM, was mapped on the chromosome close to thiD, a gene specifying phosphomethylpyrimidine kinase activity....
By conjugation and P1 transduction, a gene governing hydroxyethylthiazole kinase activity, for which we propose the designation thiM, …
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach.
Lang K, Rieder R, Micura R. Lang K, et al. Nucleic Acids Res. 2007;35(16):5370-8. doi: 10.1093/nar/gkm580. Epub 2007 Aug 9. Nucleic Acids Res. 2007. PMID: 17693433 Free PMC article.
Here, we describe ligand-induced folding of a thiamine pyrophosphate (TPP) responsive riboswitch from Escherichia coli thiM mRNA, using chemically labeled variants. Referring to a recent structure determination of the TPP/aptamer complex, each variant was synthesized with …
Here, we describe ligand-induced folding of a thiamine pyrophosphate (TPP) responsive riboswitch from Escherichia coli thiM mRNA, usi …
957 results