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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1867 1
1879 1
1885 1
1887 1
1889 1
1949 1
1950 1
1951 1
1967 1
1970 1
1973 2
1974 3
1975 2
1976 1
1977 1
1978 4
1979 2
1980 3
1982 1
1983 1
1985 7
1986 5
1987 6
1988 2
1989 7
1990 3
1991 6
1992 7
1993 6
1994 8
1995 5
1996 9
1997 4
1998 4
1999 2
2000 4
2001 6
2002 4
2003 5
2004 10
2005 6
2006 9
2007 9
2008 15
2009 9
2010 11
2011 14
2012 12
2013 16
2014 22
2015 17
2016 13
2017 18
2018 22
2019 20
2020 17
2021 25
2022 32
2023 26
2024 24
2025 23

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460 results

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Page 1
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.
Barker SJ, Thayer MB, Kim C, Tatarakis D, Simon MJ, Dial R, Nilewski L, Wells RC, Zhou Y, Afetian M, Akkapeddi P, Chappell A, Chew KS, Chow J, Clemens A, Discenza CB, Dugas JC, Dwyer C, Earr T, Ha C, Ho YS, Huynh D, Lozano EI, Jayaraman S, Kwan W, Mahon C, Pizzo M, Robles-Colmenares Y, Roche E, Sanders L, Stergioulis A, Tong R, Tran H, Zuchero Y, Estrada AA, Gadkar K, Koth CMM, Sanchez PE, Thorne RG, Watts RJ, Sandmann T, Kane LA, Rigo F, Dennis MS, Lewcock JW, DeVos SL. Barker SJ, et al. Among authors: thorne rg. Sci Transl Med. 2024 Aug 14;16(760):eadi2245. doi: 10.1126/scitranslmed.adi2245. Epub 2024 Aug 14. Sci Transl Med. 2024. PMID: 39141703
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, Jenkins K, Sanchez PE, Kane L, Miyamoto T, Chew KS, Pizzo ME, Liang N, Calvert MEK, DeVos SL, Baskaran S, Hall S, Sweeney ZK, Thorne RG, Watts RJ, Dennis MS, Silverman AP, Zuchero YJY. Kariolis MS, et al. Among authors: thorne rg. Sci Transl Med. 2020 May 27;12(545):eaay1359. doi: 10.1126/scitranslmed.aay1359. Sci Transl Med. 2020. PMID: 32461332
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Pizzo ME, Plowey ED, Khoury N, Kwan W, Abettan J, DeVos SL, Discenza CB, Earr T, Joy D, Lye-Barthel M, Roche E, Chan D, Dugas JC, Gadkar K, Hamann S, Meisner R, Sebalusky J, Silva Amaral AC, Becerra I, Chau R, Chow J, Clemens AJ, Dennis MS, Duque J, Fusaro L, Getz JA, Kariolis MS, Kim DJ, Lechtenberg KJ, Leung AW, Moshkforoush A, Nguyen HN, Ojo ES, Thomsen ER, Torres VO, Sanchez PE, Shan L, Silverman AP, Sweeney ZK, Solanoy H, Tong R, Calvert ME, Watts RJ, Thorne RG, Weinreb PH, Walsh DM, Lewcock JW, Bussiere T, Zuchero YJY. Pizzo ME, et al. Among authors: thorne rg. Science. 2025 Aug 7;389(6760):eads3204. doi: 10.1126/science.ads3204. Epub 2025 Aug 7. Science. 2025. PMID: 40773560
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L. Sun X, et al. Among authors: thorne rf. Cell Metab. 2023 Sep 5;35(9):1563-1579.e8. doi: 10.1016/j.cmet.2023.07.005. Epub 2023 Aug 4. Cell Metab. 2023. PMID: 37543034 Free article.
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM. van Lengerich B, et al. Among authors: thorne rg. Nat Neurosci. 2023 Mar;26(3):416-429. doi: 10.1038/s41593-022-01240-0. Epub 2023 Jan 12. Nat Neurosci. 2023. PMID: 36635496 Free PMC article.
CD98hc is a target for brain delivery of biotherapeutics.
Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, Akkapeddi P, Annamalai L, Bajc K, Blanchette M, Cherf GM, Earr TK, Gill A, Huynh D, Joy D, Knight KN, Lac D, Leung AW, Lexa KW, Liau NPD, Becerra I, Malfavon M, McInnes J, Nguyen HN, Lozano EI, Pizzo ME, Roche E, Sacayon P, Calvert MEK, Daneman R, Dennis MS, Duque J, Gadkar K, Lewcock JW, Mahon CS, Meisner R, Solanoy H, Thorne RG, Watts RJ, Zuchero YJY, Kariolis MS. Chew KS, et al. Among authors: thorne rg. Nat Commun. 2023 Aug 19;14(1):5053. doi: 10.1038/s41467-023-40681-4. Nat Commun. 2023. PMID: 37598178 Free PMC article.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE. Xia D, et al. Among authors: thorne rg. Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. Mol Neurodegener. 2022. PMID: 35690868 Free PMC article.
460 results