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27 results

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Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, a V2 specific HIV-1 broadly neutralising antibody, infused intravenously or subcutaneously in people without HIV-1 in the USA (HVTN 140/HPTN 101 part A): a first-in-human, phase 1 randomised trial.
Seaton KE, Paez CA, Yu C, Karuna ST, Gamble T, Miner MD, Heptinstall J, Zhang L, Gao F, Yacovone M, Spiegel H, Dumond JB, Anderson M, Piwowar-Manning E, Dye B, Tindale I, Proulx-Burns L, Trahey M, Takuva S, Takalani A, Bailey VC, Kalams SA, Scott H, Mkhize NN, Weiner JA, Ackerman ME, McElrath MJ, Pensiero M, Barouch DH, Montefiori D, Tomaras GD, Corey L, Cohen MS, Huang Y, Mahomed S, Siegel M, Kelley CF; HVTN 140/HPTN 101 study team. Seaton KE, et al. Among authors: trahey m. Lancet HIV. 2025 Jun;12(6):e405-e415. doi: 10.1016/S2352-3018(25)00012-8. Lancet HIV. 2025. PMID: 40441807 Clinical Trial.
Fixed dosing versus weight-based dosing of HIV-1 prophylactic monoclonal antibodies in adults: a post-hoc, cross-protocol pharmacokinetics modelling study.
Huang Y, Zhang L, Gelderblom H, Seaton KE, Yates NL, Paez CA, Karuna ST, Andrew P, Gamble T, Robinson ST, Ledgerwood JE, Hyrien O, Walsh SR, Gay CL, Gwira JA, Spiegel HML, Sobieszczyk ME, Mannheimer SB, Edupuganti S, Hurt CB, Stephenson KE, Yu C, Kelley CF, Mahomed S, Siegel M, Yacovone M, Pensiero MN, Donnell D, Cohen MS, Corey L, Gilbert PB, Koup RA, Tomaras GD; VRC 605, HVTN 127/HPTN 087, HVTN 130/HPTN 089, HVTN 136/HPTN 092, and HVTN 140/HPTN 101 study teams. Huang Y, et al. EBioMedicine. 2025 Jul;117:105804. doi: 10.1016/j.ebiom.2025.105804. Epub 2025 Jun 13. EBioMedicine. 2025. PMID: 40516378 Free PMC article.
Turning a corner on HIV neutralization?
Nunberg JH, Follis KE, Trahey M, LaCasse RA. Nunberg JH, et al. Among authors: trahey m. Microbes Infect. 2000 Feb;2(2):213-21. doi: 10.1016/s1286-4579(00)00267-7. Microbes Infect. 2000. PMID: 10742693 Free article. Review.
Cellular and humoral responses to an HIV DNA prime by electroporation boosted with recombinant vesicular stomatitis virus expressing HIV subtype C Env in a randomized controlled clinical trial.
Wilson GJ, Rodriguez B, Li SS, Allen M, Frank I, Rudnicki E, Trahey M, Kalams S, Hannaman D, Clarke DK, Xu R, Egan M, Eldridge J, Pensiero M, Latham T, Ferrari G, Montefiori DC, Tomaras GD, De Rosa SC, Jacobson JM, Miner MD, Elizaga M; HIV Vaccine Trials Network 112 Protocol Team. Wilson GJ, et al. Among authors: trahey m. Vaccine. 2023 Apr 17;41(16):2696-2706. doi: 10.1016/j.vaccine.2023.03.015. Epub 2023 Mar 17. Vaccine. 2023. PMID: 36935288 Free PMC article. Clinical Trial.
Rapid Development of a Registry to Accelerate COVID-19 Vaccine Clinical Trials.
Abernethy NF, McCloskey K, Trahey M, Rinn L, Broder GB, Andrasik M, Laborde R, McGhan D, Spendolini S, Marimuthu S, Kanzmeier A, Hanes J, Kublin J. Abernethy NF, et al. Among authors: trahey m. Res Sq [Preprint]. 2024 Jun 10:rs.3.rs-4397271. doi: 10.21203/rs.3.rs-4397271/v1. Res Sq. 2024. Update in: NPJ Digit Med. 2025 May 6;8(1):251. doi: 10.1038/s41746-025-01666-3. PMID: 38947011 Free PMC article. Updated. Preprint.
Efficacy of Messenger RNA-1273 Against Severe Acute Respiratory Syndrome Coronavirus 2 Acquisition in Young Adults From March to December 2021.
Stephenson KE, Marcelin JR, Pettifor AE, Janes H, Brown E, Neradilek M, Yen C, Andriesen J, Grunenberg N, Espy N, Trahey M, Fischer RSB, DeSouza CA, Shisler JL, Connick E, Houpt ER, Chu HY, McCulloh RJ, Becker-Dreps S, Vielot NA, Kalbaugh CA, Cherabuddi K, Krueger KM, Rosenberg M, Greenberg RN, Joaquin A, Immergluck LC, Corey L, Kublin JG. Stephenson KE, et al. Among authors: trahey m. Open Forum Infect Dis. 2023 Nov 2;10(11):ofad511. doi: 10.1093/ofid/ofad511. eCollection 2023 Nov. Open Forum Infect Dis. 2023. PMID: 38023544 Free PMC article.
Rapid development of a registry to accelerate COVID-19 vaccine clinical trials.
Abernethy NF, McCloskey K, Trahey M, Rinn L, Broder G, Andrasik M, Laborde R, McGhan D, Spendolini S, Marimuthu S, Kanzmeier A, Hanes J, Kublin JG. Abernethy NF, et al. Among authors: trahey m. NPJ Digit Med. 2025 May 6;8(1):251. doi: 10.1038/s41746-025-01666-3. NPJ Digit Med. 2025. PMID: 40328984 Free PMC article.
Post-COVID symptom profiles and duration in a global convalescent COVID-19 observational cohort: Correlations with demographics, medical history, acute COVID-19 severity and global region.
Karuna S, Gallardo-Cartagena JA, Theodore D, Hunidzarira P, Montenegro-Idrogo J, Hu J, Jones M, Kim V, De La Grecca R, Trahey M, Karg C, Takalani A, Polakowski L, Hutter J, Miner MD, Erdmann N, Goepfert P, Maboa R, Corey L, Gill K, Li SS; HVTN 405/HPTN 1901 Study Team. Karuna S, et al. Among authors: trahey m. J Glob Health. 2023 Jun 23;13:06020. doi: 10.7189/jogh.13.06020. J Glob Health. 2023. PMID: 37352144 Free PMC article.
27 results