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Comparative Study
. 1994 May 13;264(5161):965-8.
doi: 10.1126/science.8178155.

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

K H Grabstein  1 , J Eisenman, K Shanebeck, C Rauch, S Srinivasan, V Fung, C Beers, J Richardson, M A Schoenborn, M Ahdieh, et al.
Affiliations
Comparative Study

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

K H Grabstein et al. Science. .

Abstract

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.

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