Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Jan;6(1):249-53.
doi: 10.1002/pro.5560060128.

SAM as a protein interaction domain involved in developmental regulation

J Schultz  1 , C P Ponting, K Hofmann, P Bork
Affiliations

SAM as a protein interaction domain involved in developmental regulation

J Schultz et al. Protein Sci. 1997 Jan.

Abstract

More than 60 previously undetected SAM domain-containing proteins have been identified using profile searching methods. Among these are over 40 EPH-related receptor tyrosine kinases (RPTK), Drosophila bicaudal-C, a p53 from Loligo forbesi, and diacyglycerol-kinase isoform delta. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4355-8 - PubMed
    1. Mol Cell Biol. 1996 Oct;16(10):5597-603 - PubMed
    1. J Mol Biol. 1990 Oct 5;215(3):403-10 - PubMed
    1. Cell. 1992 Jan 24;68(2):303-22 - PubMed
    1. Genes Dev. 1992 Feb;6(2):223-32 - PubMed

Associated data