Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Oct 25;91(22):10591-5.
doi: 10.1073/pnas.91.22.10591.

ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages

M Wang  1 , S N Cohen
Affiliations

ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages

M Wang et al. Proc Natl Acad Sci U S A. .

Abstract

The Escherichia coli rne gene affects a variety of bacterial functions, including the activity of RNase E. We report the existence of a human gene (ard-1, for activator of RNA decay) that complements temperature-sensitive and deletion mutations of rne in E. coli, allowing growth of rne-defective cells, correcting abnormal cell shape, activating chemical decay of bulk mRNA, and producing site-specific cleavages characteristic of RNase E in vivo and in vitro. ard-1 encodes a highly basic 13.3-kDa proline-rich peptide that has features in common with Rne and also with eukaryotic proteins implicated in RNA binding and macromolecular transport.

PubMed Disclaimer

References

    1. Mol Gen Genet. 1977 Sep 9;154(3):279-85 - PubMed
    1. Ciba Found Symp. 1993;176:185-93; discussion 193-7 - PubMed
    1. J Bacteriol. 1994 Feb;176(3):917-22 - PubMed
    1. Cell. 1994 Mar 11;76(5):889-900 - PubMed
    1. J Biol Chem. 1994 Apr 8;269(14):10790-6 - PubMed

Publication types

MeSH terms

Associated data