Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Sep 20;273(5282):1709-14.
doi: 10.1126/science.273.5282.1709.

Small-conductance, calcium-activated potassium channels from mammalian brain

M Köhler  1 , B Hirschberg, C T Bond, J M Kinzie, N V Marrion, J Maylie, J P Adelman
Affiliations

Small-conductance, calcium-activated potassium channels from mammalian brain

M Köhler et al. Science. .

Abstract

Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.

PubMed Disclaimer

Comment in

  • A K+ channel worthy of attention.
    Hille B. Hille B. Science. 1996 Sep 20;273(5282):1677. doi: 10.1126/science.273.5282.1677. Science. 1996. PMID: 8830412 No abstract available.

Publication types

MeSH terms