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. 1997 Jul:78 ( Pt 7):1605-10.
doi: 10.1099/0022-1317-78-7-1605.

Molecular characterization of attenuated Junin virus strains

C G Albariño  1 , P D Ghiringhelli, D M Posik, M E Lozano, A M Ambrosio, A Sanchez, V Romanowski
Affiliations

Molecular characterization of attenuated Junin virus strains

C G Albariño et al. J Gen Virol. 1997 Jul.

Abstract

The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.

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