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. 1997 Apr 15;184(2):367-72.
doi: 10.1006/dbio.1997.8510.

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer

E M Joseph  1 , D A Melton
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Free article

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer

E M Joseph et al. Dev Biol. .
Free article

Abstract

We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.

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