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Page 1
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor.
Neumann EN, Bertozzi TM, Wu E, Serack F, Harvey JW, Brauer PP, Pirtle CP, Coffey A, Howard M, Kamath N, Lenz K, Guzman K, Raymond MH, Khalil AS, Deverman BE, Minikel EV, Vallabh SM, Weissman JS. Neumann EN, et al. Among authors: vallabh sm. Science. 2024 Jun 28;384(6703):ado7082. doi: 10.1126/science.ado7082. Epub 2024 Jun 28. Science. 2024. PMID: 38935715 Free PMC article.
The Patient-Scientist's Mandate.
Vallabh SM. Vallabh SM. N Engl J Med. 2020 Jan 9;382(2):107-109. doi: 10.1056/NEJMp1909471. N Engl J Med. 2020. PMID: 31914240 No abstract available.
A single-cell map of antisense oligonucleotide activity in the brain.
Mortberg MA, Gentile JE, Nadaf NM, Vanderburg C, Simmons S, Dubinsky D, Slamin A, Maldonado S, Petersen CL, Jones N, Kordasiewicz HB, Zhao HT, Vallabh SM, Minikel EV. Mortberg MA, et al. Among authors: vallabh sm. Nucleic Acids Res. 2023 Aug 11;51(14):7109-7124. doi: 10.1093/nar/gkad371. Nucleic Acids Res. 2023. PMID: 37188501 Free PMC article.
Where have prions been all our lives?
Vallabh EM, Vallabh SM. Vallabh EM, et al. Among authors: vallabh sm. Brain. 2023 Jun 1;146(6):2206-2207. doi: 10.1093/brain/awad143. Brain. 2023. PMID: 37161596 Free PMC article.
PrP turnover in vivo and the time to effect of prion disease therapeutics.
Corridon TL, O'Moore J, Lian Y, Laversenne V, Noble B, Kamath NG, Serack FE, Shaikh AB, Erickson B, Braun C, Lenz K, Howard M, Chan N, Reidenbach AG, Cabin DE, Vallabh SM, Grindeland A, Oberbeck N, Zhao HT, Minikel EV. Corridon TL, et al. Among authors: vallabh sm. bioRxiv [Preprint]. 2024 Nov 14:2024.11.12.623215. doi: 10.1101/2024.11.12.623215. bioRxiv. 2024. PMID: 39605733 Free PMC article. Preprint.
Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker.
Gentile JE, Heiss CN, Corridon TL, Mortberg MA, Fruhwürth S, Guzman K, Grötschel L, Montoliu-Gaya L, Chan K, Herring NC, Janicki T, Nhass R, Manavala Sarathy J, Erickson B, Kunz R, Erickson A, Braun C, Henry KT, Bry L, Arnold SE, Vallabh Minikel E, Zetterberg H, Vallabh SM. Gentile JE, et al. Among authors: vallabh sm. Brain Commun. 2025 May 23;7(3):fcaf175. doi: 10.1093/braincomms/fcaf175. eCollection 2025. Brain Commun. 2025. PMID: 40417399 Free PMC article.
Fluid Biomarkers in Individuals at Risk for Genetic Prion Disease up to Disease Conversion.
Vallabh SM, Mortberg MA, Allen SW, Kupferschmid AC, Kivisakk P, Hammerschlag BL, Bolling A, Trombetta BA, Devitte-McKee K, Ford AM, Sather LE, Duffy G, Rivera A, Gerber J, McManus AJ, Minikel EV, Arnold SE. Vallabh SM, et al. Neurology. 2024 Jul 23;103(2):e209506. doi: 10.1212/WNL.0000000000209506. Epub 2024 Jun 19. Neurology. 2024. PMID: 38896810 Free PMC article.
In vivo base editing extends lifespan of a humanized mouse model of prion disease.
An M, Davis JR, Levy JM, Serack FE, Harvey JW, Brauer PP, Pirtle CP, Berríos KN, Newby GA, Yeh WH, Kamath N, Mortberg M, Lian Y, Howard M, DeSouza-Lenz K, Guzman K, Thai A, Graffam S, Laversenne V, Coffey AA, Frei J, Pierce SE, Safar JG, Deverman BE, Minikel EV, Vallabh SM, Liu DR. An M, et al. Among authors: vallabh sm. Nat Med. 2025 Apr;31(4):1319-1328. doi: 10.1038/s41591-024-03466-w. Epub 2025 Jan 14. Nat Med. 2025. PMID: 39810005 Free PMC article.
36 results