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Incorporation of monophosphoryl lipid a and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations.
Vaquero AP, Calderon-Ruiz P, Gambaro R, Rivero-Berti I, Limeres MJ, Ghazi SF, Huck-Iriart C, Meyer CU, Cacicedo ML, Hankeln T, Si S, Lieberwirth I, Landfester K, Soto CA, Tekiel V, Bros M, Gehring S, Islan GA. Vaquero AP, et al. Int J Biol Macromol. 2025 Oct 1:148058. doi: 10.1016/j.ijbiomac.2025.148058. Online ahead of print. Int J Biol Macromol. 2025. PMID: 41043736 Free article.