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Year Number of Results
1981 1
1982 1
1984 1
1987 1
1989 1
1990 1
1991 3
1992 1
1993 1
1994 2
1995 1
1996 1
1998 1
1999 1
2000 4
2001 2
2002 2
2003 2
2004 2
2005 4
2006 4
2007 6
2008 7
2009 4
2010 3
2011 7
2012 5
2013 10
2014 14
2015 7
2016 6
2017 7
2018 9
2019 6
2020 6
2021 8
2022 11
2023 13
2024 15
2025 17

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181 results

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Page 1
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossù P, Bråthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bûrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M,… See abstract for full author list ➔ Bellenguez C, et al. Nat Genet. 2022 Apr;54(4):412-436. doi: 10.1038/s41588-022-01024-z. Epub 2022 Apr 4. Nat Genet. 2022. PMID: 35379992 Free PMC article.
The β-Secretase BACE1 in Alzheimer's Disease.
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, Timmers M, Tahami Monfared AA, Irizarry M, Albala B, Koyama A, Watanabe N, Kimura T, Yarenis L, Lista S, Kramer L, Vergallo A. Hampel H, et al. Among authors: vassar r. Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13. Biol Psychiatry. 2021. PMID: 32223911 Free PMC article. Review.
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Oakley H, et al. Among authors: vassar r. J Neurosci. 2006 Oct 4;26(40):10129-40. doi: 10.1523/JNEUROSCI.1202-06.2006. J Neurosci. 2006. PMID: 17021169 Free PMC article.
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease.
van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM, Zhang Z, Kuruvilla J, Camp L, Li M, Xu H, Norman JL, Cahan J, Vassar R, Chen J, Castellani RJ, Nicoll JA, Boche D, Gate D. van Olst L, et al. Among authors: vassar r. Nat Med. 2025 May;31(5):1604-1616. doi: 10.1038/s41591-025-03574-1. Epub 2025 Mar 6. Nat Med. 2025. PMID: 40050704 Free PMC article.
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Among authors: vassar r. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Sasmita AO, Depp C, Nazarenko T, Sun T, Siems SB, Ong EC, Nkeh YB, Böhler C, Yu X, Bues B, Evangelista L, Mao S, Morgado B, Wu Z, Ruhwedel T, Subramanian S, Börensen F, Overhoff K, Spieth L, Berghoff SA, Sadleir KR, Vassar R, Eggert S, Goebbels S, Saito T, Saido T, Saher G, Möbius W, Castelo-Branco G, Klafki HW, Wirths O, Wiltfang J, Jäkel S, Yan R, Nave KA. Sasmita AO, et al. Among authors: vassar r. Nat Neurosci. 2024 Sep;27(9):1668-1674. doi: 10.1038/s41593-024-01730-3. Epub 2024 Aug 5. Nat Neurosci. 2024. PMID: 39103558 Free PMC article.
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH, Swire M, Lloyd M, Giovannucci TA, Bourdenx M, Klenerman D, Vassar R, Wray S, Sala Frigerio C, Busche MA. Rajani RM, et al. Among authors: vassar r. PLoS Biol. 2024 Jul 23;22(7):e3002727. doi: 10.1371/journal.pbio.3002727. eCollection 2024 Jul. PLoS Biol. 2024. PMID: 39042667 Free PMC article.
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Vassar R, et al. Science. 1999 Oct 22;286(5440):735-41. doi: 10.1126/science.286.5440.735. Science. 1999. PMID: 10531052 Free article.
181 results