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Page 1
Showing results for vivo ro
Search for Vico RO instead (1 results)
Cholesterol Biosynthesis Inhibitor RO 48-8071 Suppresses Growth of Epithelial Ovarian Cancer Cells in Vitro and In Vivo.
Liang Y, Nephew KP, Hyder SM. Liang Y, et al. J Cancer Sci Clin Ther. 2023;7(1):1-8. doi: 10.26502/jcsct.5079185. Epub 2023 Jan 9. J Cancer Sci Clin Ther. 2023. PMID: 38105923 Free PMC article.
Finally, xenograft studies were performed to assess the ability of RO 48-8071 to inhibit the growth of EOC cells in vivo. RESULTS: We found that short-term (24-48 h) administration of pharmacological doses of RO effectively reduced the viability of drug-resis …
Finally, xenograft studies were performed to assess the ability of RO 48-8071 to inhibit the growth of EOC cells in vivo. RESU …
In Vivo Receptor Occupancy in Rodents by LC-MS/MS.
Jesudason CD, DuBois S, Johnson M, Barth VN, Need AB. Jesudason CD, et al. 2017 Mar 9. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. 2017 Mar 9. In: Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, Baell J, Brimacombe K, Chung TDY, Coussens NP, Dahlin JL, Devanarayan V, Foley TL, Glicksman M, Gorshkov K, Grotegut S, Hall MD, Hoare S, Inglese J, Iversen PW, Lal-Nag M, Li Z, Manro JR, McGee J, Norvil A, Pearson M, Riss T, Saradjian P, Sittampalam GS, Tarselli MA, Trask OJ Jr, Weidner JR, Wildey MJ, Wilson K, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004–. PMID: 28277627 Free Books & Documents. Review.
Receptor (or enzyme) Occupancy (RO) is a quantitative measure of what percentage of the total number of available target receptors is engaged by or bound to a particular ligand. ...Recent advances in the sensitivity of LC-MS/MS detectors have enabled determination of RO …
Receptor (or enzyme) Occupancy (RO) is a quantitative measure of what percentage of the total number of available target receptors is …
Benzodiazepine receptor binding in vivo with [3H]-Ro 15-1788.
Goeders NE, Kuhar MJ. Goeders NE, et al. Life Sci. 1985 Jul 29;37(4):345-55. doi: 10.1016/0024-3205(85)90505-3. Life Sci. 1985. PMID: 2989650
In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific …
In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify …
Ro 90-7501 suppresses colon cancer progression by inducing immunogenic cell death and promoting RIG-1-mediated autophagy.
Zhao X, Zhang Z, Wang J, Feng S, Jiang L, Chen L, Lei K, Wang T. Zhao X, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 3):113631. doi: 10.1016/j.intimp.2024.113631. Epub 2024 Nov 15. Int Immunopharmacol. 2024. PMID: 39549547
In this study, we investigated the anti-tumor effects of Ro 90-7501, a specific small molecule, in colon cancer cell lines (HCT8 and SW480) and in vivo models. ...In conclusion, Ro 90-7501 exhibits potent anti-tumor activity against colon cancer by inducing I …
In this study, we investigated the anti-tumor effects of Ro 90-7501, a specific small molecule, in colon cancer cell lines (HCT8 and …
In vivo binding of (3H)Ro 15-1788 in mice: comparison with the in vivo binding of (3H)flunitrazepam.
Potier MC, Prado de Carvalho L, Dodd RH, Brown CL, Rossier J. Potier MC, et al. Life Sci. 1988;43(16):1287-96. doi: 10.1016/0024-3205(88)90583-8. Life Sci. 1988. PMID: 2845217
Benzodiazepine binding sites have generally been labelled with benzodiazepine agonists: (3H)flunitrazepam and (3H)diazepam in vivo. We studied the in vivo binding of the antagonist (3H)Ro 15-1788 in mice and compared it to the in vivo binding of (3H)fl …
Benzodiazepine binding sites have generally been labelled with benzodiazepine agonists: (3H)flunitrazepam and (3H)diazepam in vivo. W …
Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513.
Pym LJ, Cook SM, Rosahl T, McKernan RM, Atack JR. Pym LJ, et al. Br J Pharmacol. 2005 Nov;146(6):817-25. doi: 10.1038/sj.bjp.0706392. Br J Pharmacol. 2005. PMID: 16184188 Free PMC article.
Essentially all membrane binding to DS+DIS receptors could be displaced by unlabelled Ro 15-4513 or bretazenil, with respective ID50 values of 0.35 and 1.2 mg kg(-1). A dose of 30 mg kg(-1) lorazepam was used to block all DS receptors in a [3H]Ro 15-1788 in vivo …
Essentially all membrane binding to DS+DIS receptors could be displaced by unlabelled Ro 15-4513 or bretazenil, with respective ID50 …
Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites.
Zheng SW, Xiao SY, Wang J, Hou W, Wang YP. Zheng SW, et al. Molecules. 2019 Aug 17;24(16):2985. doi: 10.3390/molecules24162985. Molecules. 2019. PMID: 31426477 Free PMC article.
We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight. ...The results suggest that the metabolites …
We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro consider …
[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
Koe BK, Kondratas E, Russo LL. Koe BK, et al. Eur J Pharmacol. 1987 Oct 27;142(3):373-84. doi: 10.1016/0014-2999(87)90076-8. Eur J Pharmacol. 1987. PMID: 2892685
Administration of the benzodiazepine receptor antagonist, [3H]Ro 15-1788, to mice intravenously was found to label these receptors in brain. Binding of [3H]Ro 15-1788 in vivo was strongly blocked by pretreating mice with clonazepam or diazepam. Marked enhance …
Administration of the benzodiazepine receptor antagonist, [3H]Ro 15-1788, to mice intravenously was found to label these receptors in …
In vivo pharmacology of Ro 46-2005, the first synthetic nonpeptide endothelin receptor antagonist: implications for endothelin physiology.
Clozel M, Breu V, Gray GA, Löffler BM. Clozel M, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9. doi: 10.1097/00005344-199322008-00099. J Cardiovasc Pharmacol. 1993. PMID: 7509992
Ro 46-2005 is a small-molecular-weight nonpeptide antagonist of the endothelin (ET), ETA and ETB receptors, chemically derived from a class of compounds identified by systematic screening of chemicals. In vivo, Ro 46-2005 inhibited the depressor and, only at …
Ro 46-2005 is a small-molecular-weight nonpeptide antagonist of the endothelin (ET), ETA and ETB receptors, chemically derived from a …
Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo.
Potier MC, Prado de Carvalho L, Venault P, Chapouthier G, Rossier J. Potier MC, et al. Eur J Pharmacol. 1988 Oct 26;156(1):169-72. doi: 10.1016/0014-2999(88)90161-6. Eur J Pharmacol. 1988. PMID: 2850207
Benzodiazepine receptor occupancy by the full agonist, diazepam, and by the two putative partial agonists, Ro 16-6028 and Ro 17-1812, was measured by inhibition of in vivo [3H]Ro 15-1788 binding in mouse brain and was correlated with their pharmacologi …
Benzodiazepine receptor occupancy by the full agonist, diazepam, and by the two putative partial agonists, Ro 16-6028 and Ro 1 …
6,038 results