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Page 1
Showing results for vitro mt
Search for Vintro MT instead (1 results)
A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima.
Sun N, Malide D, Liu J, Rovira II, Combs CA, Finkel T. Sun N, et al. Nat Protoc. 2017 Aug;12(8):1576-1587. doi: 10.1038/nprot.2017.060. Epub 2017 Jul 13. Nat Protoc. 2017. PMID: 28703790
This protocol also describes how to use confocal microscopy to visualize mitophagy in living tissues obtained from mt-Keima transgenic mice. With this protocol, the mt-Keima probe can reliably be imaged within the first 60 min after tissue collection. ...Typically, …
This protocol also describes how to use confocal microscopy to visualize mitophagy in living tissues obtained from mt-Keima transgeni …
Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway.
Liu W, Yu M, Xie D, Wang L, Ye C, Zhu Q, Liu F, Yang L. Liu W, et al. Stem Cell Res Ther. 2020 Jun 29;11(1):259. doi: 10.1186/s13287-020-01756-x. Stem Cell Res Ther. 2020. PMID: 32600435 Free PMC article.
In this study, we investigated whether melatonin (MT)-pretreated MSCs-derived exosomes (MT-Exo) could exert superior effects on diabetic wound healing, and we attempted to elucidate the underlying mechanism. METHODS: For the evaluation of the anti-inflammator …
In this study, we investigated whether melatonin (MT)-pretreated MSCs-derived exosomes (MT-Exo) could exert superior effects o …
Polymorphisms in the MT-ATP6 and MT-CYB genes in in vitro fertilization failure.
Mao GH, Wang YN, Xu M, Wang WL, Tan L, Tao SB. Mao GH, et al. Mitochondrial DNA. 2015 Feb;26(1):20-4. doi: 10.3109/19401736.2013.840612. Epub 2013 Oct 9. Mitochondrial DNA. 2015. PMID: 24102627
The purpose of this study was to investigate whether fertilization failure after in vitro fertilization could be explained by polymorphisms in MT-ATP6 and MT-CYB genes. We performed a prospective comparative study of 111 fresh IVF cycles in Han Chinese betwee …
The purpose of this study was to investigate whether fertilization failure after in vitro fertilization could be explained by polymor …
Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users.
McKenzie C, Sutcliffe OB, Read KD, Scullion P, Epemolu O, Fletcher D, Helander A, Beck O, Rylski A, Antonides LH, Riley J, Smith SA, Nic Daeid N. McKenzie C, et al. Forensic Toxicol. 2018;36(2):359-374. doi: 10.1007/s11419-018-0413-1. Epub 2018 Apr 5. Forensic Toxicol. 2018. PMID: 29963206 Free PMC article.
MT-45, 2F-, 3F- and 4F-MT-45 were synthesised and reference analytical data were reported. ...The major MT-45 metabolites identified in human in vitro studies and in authenticated human urine were phase I metabolites and should be incorporated as analy
MT-45, 2F-, 3F- and 4F-MT-45 were synthesised and reference analytical data were reported. ...The major MT-45 metabolit
Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena group I intron ribozyme.
Lee KH, Kim S, Song J, Han SR, Kim JH, Lee SW. Lee KH, et al. Mol Ther Nucleic Acids. 2023 Aug 1;33:587-598. doi: 10.1016/j.omtn.2023.07.034. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37637208 Free PMC article.
Circular RNA (circRNA) has various advantages over linear mRNA that is gaining success as a new vaccine and therapeutic agent. Thus, circRNA and its engineering methods have attracted attention recently. In this study, we developed a new in vitro circRNA engineering …
Circular RNA (circRNA) has various advantages over linear mRNA that is gaining success as a new vaccine and therapeutic agent. Thus, circRNA …
In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation.
Newman SP, Chan HK. Newman SP, et al. Adv Drug Deliv Rev. 2020 Dec;167:135-147. doi: 10.1016/j.addr.2020.06.023. Epub 2020 Jun 25. Adv Drug Deliv Rev. 2020. PMID: 32593641 Review.
MTs that mimic the human anatomy, coupled with simulated breathing patterns, have yielded estimates of lung dose from in vitro data that closely match those from in vivo gamma scintigraphic or pharmacokinetic studies. However, different models of MTs do not always yield id …
MTs that mimic the human anatomy, coupled with simulated breathing patterns, have yielded estimates of lung dose from in vitro data t …
Senescent Hepatocytes in Decompensated Liver Show Reduced UPR(MT) and Its Key Player, CLPP, Attenuates Senescence In Vitro.
Sen B, Rastogi A, Nath R, Shasthry SM, Pamecha V, Pandey S, Gupta KJ, Sarin SK, Trehanpati N, Ramakrishna G. Sen B, et al. Cell Mol Gastroenterol Hepatol. 2019;8(1):73-94. doi: 10.1016/j.jcmgh.2019.03.001. Epub 2019 Mar 13. Cell Mol Gastroenterol Hepatol. 2019. PMID: 30878663 Free PMC article.
Aim of this study was to identify hepatocyte senescence and the role of UPR(MT) in cryptogenic cirrhosis. METHODS: Doxorubicin was used to induce senescence in non-neoplastic hepatocytes (PH5CH8) and hepatoma cells (HepG2 and Huh7). ...Dysfunctional mitochondria and …
Aim of this study was to identify hepatocyte senescence and the role of UPR(MT) in cryptogenic cirrhosis. METHODS: Doxorubicin …
Lead(II) Binding in Metallothioneins.
Wong DL, Merrifield-MacRae ME, Stillman MJ. Wong DL, et al. Met Ions Life Sci. 2017 Apr 10;17:/books/9783110434330/9783110434330-009/9783110434330-009.xml. doi: 10.1515/9783110434330-009. Met Ions Life Sci. 2017. PMID: 28731302 Free article. Review.
In vitro, metallation with a wide range of metals (especially mercury, arsenic, and lead) has been reported using a variety of analytical methods. To fully understand MT and its role with lead metabolism, we will describe how MT interacts with a wide v …
In vitro, metallation with a wide range of metals (especially mercury, arsenic, and lead) has been reported using a variety of analyt …
Identification of MT-45 Metabolites: In Silico Prediction, In Vitro Incubation with Rat Hepatocytes and In Vivo Confirmation.
Montesano C, Vannutelli G, Fanti F, Vincenti F, Gregori A, Rita Togna A, Canazza I, Marti M, Sergi M. Montesano C, et al. J Anal Toxicol. 2017 Oct 1;41(8):688-697. doi: 10.1093/jat/bkx058. J Anal Toxicol. 2017. PMID: 28985323
The detected metabolites were firstly predicted in silico, then incubation of the drug with rat hepatocytes was carried out and the obtained metabolites were identified by LC-HRMS, with retention times, mass shift between theoretical mass and observed mass (<5 ppm), peak abund …
The detected metabolites were firstly predicted in silico, then incubation of the drug with rat hepatocytes was carried out and the obtained …
Engineered DBCO+PD-1 Nanovesicles Carrying 1-MT for Cancer-Targeted Immunotherapy.
Xu X, Liu L, Wang H, Li W, Zou Y, Zeng Y, Yang Q, Bai D, Dai D. Xu X, et al. ACS Biomater Sci Eng. 2022 Nov 14;8(11):4819-4826. doi: 10.1021/acsbiomaterials.2c00639. Epub 2022 Oct 7. ACS Biomater Sci Eng. 2022. PMID: 36206367
In this study, we bioengineered cell membrane-derived nanovesicles (NVs) presenting PD-1 proteins and dibenzocyclooctyne (DBCO) to encapsulate 1-methyltryptophan (1-MT) (DBCO+PD-1@1-MT NVs). DBCO can specifically interact with N-azidoacetylmannosamine-tetraacetylate …
In this study, we bioengineered cell membrane-derived nanovesicles (NVs) presenting PD-1 proteins and dibenzocyclooctyne (DBCO) to encapsula …
478,817 results
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