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Page 1
Showing results for ligand ll
Search for Wiegand LL instead (1 results)
Radiation-induced amphiregulin drives tumour metastasis.
Piffkó A, Yang K, Panda A, Heide J, Tesak K, Wen C, Zawieracz K, Wang L, Naccasha EZ, Bugno J, Fu Y, Chen D, Donle L, Lengyel E, Tilley DG, Mack M, Rock RS, Chmura SJ, Vokes EE, He C, Pitroda SP, Liang HL, Weichselbaum RR. Piffkó A, et al. Nature. 2025 Jul;643(8072):810-819. doi: 10.1038/s41586-025-08994-0. Epub 2025 May 14. Nature. 2025. PMID: 40369065
Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expressing myeloid cells toward an immunosuppressive phenotype and reduces phagocytosis. ...
Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expres …
A large peptidome dataset improves HLA class I epitope prediction across most of the human population.
Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CR, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justesen S, Stevens J, Lane WJ, Eisenhaure T, Lan Zhang G, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB. Sarkizova S, et al. Nat Biotechnol. 2020 Feb;38(2):199-209. doi: 10.1038/s41587-019-0322-9. Epub 2019 Dec 16. Nat Biotechnol. 2020. PMID: 31844290 Free PMC article.
These models predicted endogenous HLA class I-associated ligands with 1.5-fold improvement in positive predictive value compared with existing tools and correctly identified >75% of HLA-bound peptides that were observed experimentally in 11 patient-derived tumor cell li …
These models predicted endogenous HLA class I-associated ligands with 1.5-fold improvement in positive predictive value compared with …
Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, He R, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ. Ma P, et al. Circulation. 2024 Jan 2;149(1):48-66. doi: 10.1161/CIRCULATIONAHA.122.062551. Epub 2023 Sep 25. Circulation. 2024. PMID: 37746718 Free PMC article.
BACKGROUND: Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1 (programmed cell death protein 1)/PD-L1 (programmed death-ligand 1) or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), have revolutionized cancer management but are associated with devastating …
BACKGROUND: Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1 (programmed cell death protein 1)/PD-L1 (programmed death-liga …
CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells.
Feng G, Bajpai G, Ma P, Koenig A, Bredemeyer A, Lokshina I, Lai L, Förster I, Leuschner F, Kreisel D, Lavine KJ. Feng G, et al. Circulation. 2022 Mar 8;145(10):765-782. doi: 10.1161/CIRCULATIONAHA.121.055888. Epub 2022 Feb 3. Circulation. 2022. PMID: 35113652 Free PMC article.
METHODS: We used mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate CCL17 (C-C chemokine ligand 17). We used Ccl17 knockout mice, flow cytometry, RNA sequencing, biochemica …
METHODS: We used mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyo …
Molecular mechanisms of LL-37-induced receptor activation: An overview.
Verjans ET, Zels S, Luyten W, Landuyt B, Schoofs L. Verjans ET, et al. Peptides. 2016 Nov;85:16-26. doi: 10.1016/j.peptides.2016.09.002. Epub 2016 Sep 5. Peptides. 2016. PMID: 27609777 Review.
How LL-37 is able to affect multiple receptors is currently not well understood. So far, the mechanistic details underlying receptor activation are poorly investigated and evidence for a conventional ligand/receptor interaction is scarce. Over the past few decades, …
How LL-37 is able to affect multiple receptors is currently not well understood. So far, the mechanistic details underlying receptor …
Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils.
Zhang Z, Cherryholmes G, Chang F, Rose DM, Schraufstatter I, Shively JE. Zhang Z, et al. Eur J Immunol. 2009 Nov;39(11):3181-94. doi: 10.1002/eji.200939496. Eur J Immunol. 2009. PMID: 19750480 Free PMC article.
Among all ligands tested (ATP, BzATP, WKYMVm, CXCL1, and LL-37), only LL-37 stimulated migration of monocytes (CXCR2(+) and FPR2(+)) and migration was inhibited by the CXCR2 inhibitor SB225002. Moreover, CXCR2 but not CXCR1 was internalized in LL-37-tr …
Among all ligands tested (ATP, BzATP, WKYMVm, CXCL1, and LL-37), only LL-37 stimulated migration of monocytes (CXCR2(+) …
Cathelicidins Modulate TLR-Activation and Inflammation.
Scheenstra MR, van Harten RM, Veldhuizen EJA, Haagsman HP, Coorens M. Scheenstra MR, et al. Front Immunol. 2020 Jun 9;11:1137. doi: 10.3389/fimmu.2020.01137. eCollection 2020. Front Immunol. 2020. PMID: 32582207 Free PMC article. Review.
We review the available literature based on TLR ligand types, which can roughly be divided into lipidic ligands, such as LPS and lipoproteins, and nucleic-acid ligands, such as RNA and DNA. For both ligand types, we describe how direct cathelicidin- …
We review the available literature based on TLR ligand types, which can roughly be divided into lipidic ligands, such as LPS a …
CCL21/CCR7 axis as a therapeutic target for autoimmune diseases.
Han L, Zhang L. Han L, et al. Int Immunopharmacol. 2023 Aug;121:110431. doi: 10.1016/j.intimp.2023.110431. Epub 2023 Jun 16. Int Immunopharmacol. 2023. PMID: 37331295 Review.
Chemokine receptor 7 (CCR7) is a G protein-coupled receptor containing 7 transmembrane domains that is expressed on various cells, such as naive T/B cells, central memory T cells, regulatory T cells, immature/mature dendritic cells (DCs), natural killer cells, and a minority of t …
Chemokine receptor 7 (CCR7) is a G protein-coupled receptor containing 7 transmembrane domains that is expressed on various cells, such as n …
Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor.
Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, Babu MM, Volkman BF. Kleist AB, et al. Science. 2022 Jul 8;377(6602):222-228. doi: 10.1126/science.abj4922. Epub 2022 Jul 7. Science. 2022. PMID: 35857540 Free PMC article.
Here, we performed nuclear magnetic resonance (NMR) experiments on (13)CH(3)-epsilon-methionine-labeled ACKR3, revealing that beta-arrestin recruitment is associated with conformational exchange at key regions of the extracellular ligand-binding pocket and intracellular be …
Here, we performed nuclear magnetic resonance (NMR) experiments on (13)CH(3)-epsilon-methionine-labeled ACKR3, revealing that beta-arrestin …
DNA binding studies of PdCl2(LL) (LL = chelating diamine ligand: N,N-dimethyltrimethylenediamine) complex.
Kashanian S, Shahabadi N, Roshanfekr H, Shalmashi K, Omidfar K. Kashanian S, et al. Biochemistry (Mosc). 2008 Aug;73(8):929-36. doi: 10.1134/s0006297908080117. Biochemistry (Mosc). 2008. PMID: 18774940
The interaction of native calf thymus DNA with the Pd(II) complex, PdCl2(LL) (LL = chelating diamine ligand: N,N-dimethyltrimethylenediamine), in 10 mM Hepes aqueous solutions at neutral pH has been monitored as a function of metal complex/DNA molar ratio by …
The interaction of native calf thymus DNA with the Pd(II) complex, PdCl2(LL) (LL = chelating diamine ligand: N,N-dimeth …
1,473 results