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Page 1
Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial.
Cortes J, Cescon DW, Rugo HS, Nowecki Z, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Holgado E, Iwata H, Masuda N, Otero MT, Gokmen E, Loi S, Guo Z, Zhao J, Aktan G, Karantza V, Schmid P; KEYNOTE-355 Investigators. Cortes J, et al. Lancet. 2020 Dec 5;396(10265):1817-1828. doi: 10.1016/S0140-6736(20)32531-9. Lancet. 2020. PMID: 33278935 Clinical Trial.
Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer.
Partridge AH, Niman SM, Ruggeri M, Peccatori FA, Azim HA Jr, Colleoni M, Saura C, Shimizu C, Sætersdal AB, Kroep JR, Mailliez A, Warner E, Borges VF, Amant F, Gombos A, Kataoka A, Rousset-Jablonski C, Borstnar S, Takei J, Lee JE, Walshe JM, Ruíz-Borrego M, Moore HCF, Saunders C, Bjelic-Radisic V, Susnjar S, Cardoso F, Smith KL, Ferreiro T, Ribi K, Ruddy K, Kammler R, El-Abed S, Viale G, Piccart M, Korde LA, Goldhirsch A, Gelber RD, Pagani O; International Breast Cancer Study Group; POSITIVE Trial Collaborators. Partridge AH, et al. N Engl J Med. 2023 May 4;388(18):1645-1656. doi: 10.1056/NEJMoa2212856. N Engl J Med. 2023. PMID: 37133584 Free PMC article. Clinical Trial.
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens.
Damo M, Hornick NI, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza JL, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky WE, Leventhal JS, Krishnaswamy S, Joshi NS. Damo M, et al. Among authors: william i. Nature. 2023 Jul;619(7968):151-159. doi: 10.1038/s41586-023-06217-y. Epub 2023 Jun 21. Nature. 2023. PMID: 37344588 Free PMC article.
A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response.
Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS. Connolly KA, et al. Among authors: william i. Sci Immunol. 2021 Oct;6(64):eabg7836. doi: 10.1126/sciimmunol.abg7836. Epub 2021 Sep 2. Sci Immunol. 2021. PMID: 34597124 Free PMC article.
STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma.
Najem H, Lea ST, Tripathi S, Hurley L, Chen CH, William I, Sooreshjani M, Bowie M, Hartley G, Dussold C, Pacheco S, Dmello C, Lee-Chang C, McCortney K, Steffens A, Walshon J, Ott M, Wei J, Marisetty A, Balyasnikova I, Stupp R, Lukas RV, Hu J, James CD, Horbinski CM, Lesniak MS, Ashley DM, Priebe W, Platanias LC, Curran MA, Heimberger AB. Najem H, et al. Among authors: william i. J Clin Invest. 2024 Jun 17;134(12):e175033. doi: 10.1172/JCI175033. J Clin Invest. 2024. PMID: 38941297 Free PMC article.
Inducible de novo expression of neoantigens in tumor cells and mice.
Damo M, Fitzgerald B, Lu Y, Nader M, William I, Cheung JF, Connolly KA, Foster GG, Akama-Garren E, Lee DY, Chang GP, Gocheva V, Schmidt LM, Boileve A, Wilson JH, Cui C, Monroy I, Gokare P, Cabeceiras P, Jacks T, Joshi NS. Damo M, et al. Among authors: william i. Nat Biotechnol. 2021 Jan;39(1):64-73. doi: 10.1038/s41587-020-0613-1. Epub 2020 Jul 27. Nat Biotechnol. 2021. PMID: 32719479 Free PMC article.
Preliminary predictive criteria for COVID-19 cytokine storm.
Caricchio R, Gallucci M, Dass C, Zhang X, Gallucci S, Fleece D, Bromberg M, Criner GJ; Temple University COVID-19 Research Group. Caricchio R, et al. Ann Rheum Dis. 2021 Jan;80(1):88-95. doi: 10.1136/annrheumdis-2020-218323. Epub 2020 Sep 25. Ann Rheum Dis. 2021. PMID: 32978237 Free article. Review.
Methods for Detecting PER2:LUCIFERASE Bioluminescence Rhythms in Freely Moving Mice.
Martin-Burgos B, Wang W, William I, Tir S, Mohammad I, Javed R, Smith S, Cui Y, Arzavala J, Mora D, Smith CB, van der Vinne V, Molyneux PC, Miller SC, Weaver DR, Leise TL, Harrington ME. Martin-Burgos B, et al. Among authors: william i. J Biol Rhythms. 2022 Feb;37(1):78-93. doi: 10.1177/07487304211062829. Epub 2021 Dec 7. J Biol Rhythms. 2022. PMID: 34873943 Free PMC article.
13 results