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. 1985 Nov;4(11):2861-7.
doi: 10.1002/j.1460-2075.1985.tb04015.x.

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes

E Winter, A Radbruch, U Krawinkel

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes

E Winter et al. EMBO J. 1985 Nov.

Abstract

Four potentially productive and two non-productive VDJ gene segments were isolated from the DNA of mouse B-lymphocytes which had been polyclonally activated by bacterial lipopolysaccharide (LPS). Three VDJ regions exhibit VH genes which stem from two novel VH gene families. The complexity of these families is 5-9 genes. One of the non-productive VDJ regions exhibits a D segment which may have been generated by joining of two DSP2 segments. Both non-productive VDJ regions appear to contain rearranged pseudo VH genes. Three potential somatic mutations distributed over two productive VDJ regions are observed.

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