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Comparative Study
. 1986 Jul 14;203(1):25-30.
doi: 10.1016/0014-5793(86)81429-6.

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

S Seino, M Welsh, G I Bell, S J Chan, D F Steiner
Free article
Comparative Study

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

S Seino et al. FEBS Lett. .
Free article

Abstract

A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.

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