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Comparative Study
. 1987 Jan 12;15(1):181-98.
doi: 10.1093/nar/15.1.181.

The pro alpha 2(V) collagen gene is evolutionarily related to the major fibrillar-forming collagens

D Weil, M Bernard, S Gargano, F Ramirez
Free PMC article
Comparative Study

The pro alpha 2(V) collagen gene is evolutionarily related to the major fibrillar-forming collagens

D Weil et al. Nucleic Acids Res. .
Free PMC article

Erratum in

  • Nucleic Acids Res 1987 May 11;15(9):3946

Abstract

A number of overlapping cDNA clones, covering 5.2 kb of sequences which code for the human pro alpha 2(V) collagen chain, have been isolated. Analysis of the structural data have indicated a close evolutionary kinship between the pro alpha 2(V) chain and the major fibrillar collagen types. Isolation and analysis of an 8 kb genomic fragment has further supported this notion by revealing a homologous arrangement of nine triple-helical domain exons. These studies have therefore provided conclusive evidence which categorizes the Type V collagen as a member of the Group 1 molecules, or fibrillar-forming collagens.

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References

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