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Comparative Study
. 1987 Feb 11;15(3):959-70.
doi: 10.1093/nar/15.3.959.

Genetic organization of the c-sis transcription unit

A M Van den Ouweland, J J Van Groningen, J A Schalken, H W Van Neck, H P Bloemers, W J Van de Ven
Free PMC article
Comparative Study

Genetic organization of the c-sis transcription unit

A M Van den Ouweland et al. Nucleic Acids Res. .
Free PMC article

Abstract

The structure and genetic organization of the transcription unit of the c-sis proto-oncogene was determined. Comparative nucleotide sequence analysis of the exon sequences of feline and human c-sis revealed a very high degree of homology. The cap site as well as the poly(A)-addition site of the sis transcript of each species was identified and found in similar positions. An insert of 4 amino acids was found in the deduced translational product of feline c-sis and it was located at the amino-terminus of the region that constituted the platelet-derived growth factor domain. An insert of 149 bp present at the 5' end of exon 7 of human c-sis but absent in the simian sarcoma virus v-sis oncogene was also present in the feline c-sis proto-oncogene.

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