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Comparative Study
. 1989 Feb 28;159(1):140-7.
doi: 10.1016/0006-291x(89)92415-7.

The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (HSP 90) reveals a "DNA like" structure: potential site of interaction with steroid receptors

N Binart  1 , B Chambraud, B Dumas, D A Rowlands, C Bigogne, J M Levin, J Garnier, E E Baulieu, M G Catelli
Affiliations
Comparative Study

The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (HSP 90) reveals a "DNA like" structure: potential site of interaction with steroid receptors

N Binart et al. Biochem Biophys Res Commun. .

Abstract

We report cDNA sequence, the complete derived aa sequence, and a predicted secondary structure of the chick hsp 90, a protein which has been found to form complexes with steroid hormone receptors. The modelling of the most negatively charged "region A" indicates that the alpha-helices of this portion of hsp 90 mimick DNA configuration. We propose that this region can, in absence of hormone, interact with and cap the positively charged DNA-binding domain of steroid receptors.

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