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. 1989 Dec 22;1009(3):283-6.
doi: 10.1016/0167-4781(89)90115-2.

Characteristic sequences in the upstream region of the human tyrosinase gene

H Kikuchi  1 , H Miura, H Yamamoto, T Takeuchi, T Dei, M Watanabe
Affiliations

Characteristic sequences in the upstream region of the human tyrosinase gene

H Kikuchi et al. Biochim Biophys Acta. .

Abstract

A human tyrosinase gene containing a 5'-flanking region and the first exon was isolated from a normal human liver library using mouse tyrosinase cDNA as a probe for screening. In the 5'-upstream region of transcriptional start sites, there is a putative TATA box and CAAT box and some palindromic sequences. A characteristic sequence of (GA:TCn, which can assume a hinged-DNA structure, was present from -869 nt to -633 nt in this 5'-flanking region.

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