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Comparative Study
. 1990 Apr 15;267(2):399-405.
doi: 10.1042/bj2670399.

Mouse phenylalanine hydroxylase. Homology and divergence from human phenylalanine hydroxylase

F D Ledley  1 , H E Grenett, B S Dunbar, S L Woo
Affiliations
Comparative Study

Mouse phenylalanine hydroxylase. Homology and divergence from human phenylalanine hydroxylase

F D Ledley et al. Biochem J. .

Abstract

The laboratory mouse represents an important model for the study of phenylalanine metabolism and the pathochemistry of phenylketonuria, yet mouse phenylalanine hydroxylase (PAH) has not been extensively studied. We report the cloning and sequencing of a mouse PAH cDNA, the expression of enzymic activity from the mouse PAH cDNA clone and the identification of mouse PAH and human PAH by two-dimensional PAGE of liver samples. These data confirm the expected homology of mouse PAH and human PAH and suggest differences in the primary sequence and the phosphorylation state of the two enzymes.

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References

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