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Comparative Study
. 1992 May 7;1131(1):99-102.
doi: 10.1016/0167-4781(92)90105-9.

Molecular cloning of substance P receptor cDNA from guinea-pig uterus

V Gorbulev  1 , A Akhundova, H Luzius, F Fahrenholz
Affiliations
Free article
Comparative Study

Molecular cloning of substance P receptor cDNA from guinea-pig uterus

V Gorbulev et al. Biochim Biophys Acta. .
Free article

Abstract

A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative ligand affinity in the order: SP much greater than neurokinin A greater than neurokinin B.

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