Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jun 11;20(11):2767-72.
doi: 10.1093/nar/20.11.2767.

Heterologous activation of the actinorhodin biosynthetic pathway in Streptomyces lividans

N M Romero  1 , V Parro, F Malpartida, R P Mellado
Affiliations
Free PMC article

Heterologous activation of the actinorhodin biosynthetic pathway in Streptomyces lividans

N M Romero et al. Nucleic Acids Res. .
Free PMC article

Abstract

A DNA fragment of Streptomyces fradiae is able to activate the antibiotic actinorhodin biosynthetic pathway when cloned in Streptomyces lividans. The activator DNA region has been sequenced and its transcription initiation and termination sites accurately mapped in vivo. This DNA encodes a 132 nucleotides long transcript which is apparently responsible for the actinorhodin production phenotype, possibly acting as an antisense RNA. The sequence of the activator gene revealed no homology with any other known Streptomyces coelicolor genes concerned with actinorhodin biosynthesis or its pleiotropic regulation.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1991 May 25;19(10):2623-7 - PubMed
    1. Cell. 1979 Oct;18(2):485-99 - PubMed
    1. Cell. 1991 Aug 23;66(4):769-80 - PubMed
    1. Mol Gen Genet. 1986 Jun;203(3):468-78 - PubMed
    1. Gene. 1987;56(2-3):277-82 - PubMed

Publication types

Associated data

LinkOut - more resources