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. 1987 Oct 19;223(1):104-12.
doi: 10.1016/0014-5793(87)80518-5.

Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs

V Witzemann  1 , B Barg, Y Nishikawa, B Sakmann, S Numa
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Free article

Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs

V Witzemann et al. FEBS Lett. .
Free article

Abstract

The contents of the mRNAs encoding the gamma- and epsilon-subunits of the nicotinic acetylcholine receptor as well as the single-channel properties of the receptor have been assessed in innervated, denervated and reinnervated rat muscle. The changes in abundance of the gamma- and epsilon-subunit mRNAs correlate with the changes in relative density of two classes of acetylcholine receptor channels. The results support the view that a switch in the relative abundance of the gamma- and epsilon-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle.

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