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Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability.
Dürauer S, Kang HS, Wiebeler C, Machida Y, Schnapka DS, Yaneva D, Renz C, Götz MJ, Weickert P, Major AC, Rahmanto AS, Gutenthaler-Tietze SM, Daumann LJ, Beli P, Ulrich HD, Sattler M, Machida YJ, Schwierz N, Stingele J. Dürauer S, et al. Among authors: yaneva d. Nat Commun. 2025 Jul 21;16(1):5422. doi: 10.1038/s41467-025-61224-z. Nat Commun. 2025. PMID: 40691134 Free PMC article.
A non-proteolytic release mechanism for HMCES-DNA-protein crosslinks.
Donsbach M, Dürauer S, Grünert F, Nguyen KT, Nigam R, Yaneva D, Weickert P, Bezalel-Buch R, Semlow DR, Stingele J. Donsbach M, et al. Among authors: yaneva d. EMBO J. 2023 Sep 18;42(18):e113360. doi: 10.15252/embj.2022113360. Epub 2023 Jul 31. EMBO J. 2023. PMID: 37519246 Free PMC article.
A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial.
Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS; Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators. Binkley N, et al. J Bone Miner Res. 2012 Aug;27(8):1821-9. doi: 10.1002/jbmr.1602. J Bone Miner Res. 2012. PMID: 22437792 Free article. Clinical Trial.